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应用两种对比剂的光谱光子计数 CT 检测血管内修复术后内漏的实验可行性。

Experimental feasibility of spectral photon-counting computed tomography with two contrast agents for the detection of endoleaks following endovascular aortic repair.

机构信息

Department of Diagnostic and Interventional Radiology, Technische Universität München, Ismaningerstr. 22, 81675, Munich, Germany.

CREATIS, CNRS UMR 5220, INSERM U1206, INSA, Lyon, France.

出版信息

Eur Radiol. 2018 Aug;28(8):3318-3325. doi: 10.1007/s00330-017-5252-7. Epub 2018 Feb 19.

Abstract

OBJECTIVES

After endovascular aortic repair (EVAR), discrimination of endoleaks and intra-aneurysmatic calcifications within the aneurysm often requires multiphase computed tomography (CT). Spectral photon-counting CT (SPCCT) in combination with a two-contrast agent injection protocol may provide reliable detection of endoleaks with a single CT acquisition.

METHODS

To evaluate the feasibility of SPCCT, the stent-lined compartment of an abdominal aortic aneurysm phantom was filled with a mixture of iodine and gadolinium mimicking enhanced blood. To represent endoleaks of different flow rates, the adjacent compartments contained either one of the contrast agents or calcium chloride to mimic intra-aneurysmatic calcifications. After data acquisition with a SPCCT prototype scanner with multi-energy bins, material decomposition was performed to generate iodine, gadolinium and calcium maps.

RESULTS

In a conventional CT slice, Hounsfield units (HU) of the compartments were similar ranging from 147 to 168 HU. Material-specific maps differentiate the distributions within the compartments filled with iodine, gadolinium or calcium.

CONCLUSION

SPCCT may replace multiphase CT to detect endoleaks without sacrificing diagnostic accuracy. It is a unique feature of our method to capture endoleak dynamics and allow reliable distinction from intra-aneurysmatic calcifications in a single scan, thereby enabling a significant reduction of radiation exposure.

KEY POINTS

• SPCCT might enable advanced endoleak detection. • Material maps derived from SPCCT can differentiate iodine, gadolinium and calcium. • SPCCT may potentially reduce radiation burden for EVAR patients under post-interventional surveillance.

摘要

目的

在血管内主动脉修复(EVAR)后,通常需要多期计算机断层扫描(CT)来区分内漏和动脉瘤内的钙化。结合双对比剂注射方案的能谱光子计数 CT(SPCCT)可能可以通过单次 CT 采集可靠地检测内漏。

方法

为了评估 SPCCT 的可行性,使用碘和钆混合物模拟增强血液来填充腹主动脉瘤模型的支架包裹腔室。为了模拟不同流速的内漏,相邻腔室分别包含一种对比剂或氯化钙来模拟动脉瘤内的钙化。使用具有多能量-bin 的 SPCCT 原型扫描仪采集数据后,进行物质分解以生成碘、钆和钙图。

结果

在常规 CT 切片中,填充碘、钆或钙的腔室的 CT 值(HU)相似,范围为 147 至 168 HU。物质特异性地图可区分填充碘、钆或钙的腔室的分布。

结论

SPCCT 可以替代多期 CT 来检测内漏,而不会牺牲诊断准确性。我们的方法具有独特的优势,可以在单次扫描中捕获内漏动力学,并可靠地区分内漏和动脉瘤内的钙化,从而显著降低辐射暴露。

关键点

• SPCCT 可能可以实现先进的内漏检测。

• SPCCT 衍生的物质地图可以区分碘、钆和钙。

• SPCCT 可能会降低 EVAR 患者在介入后监测中的辐射负担。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e28/6028848/c798442f8322/330_2017_5252_Fig1_HTML.jpg

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