Department of Surgery, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-ku, Kitakyushu, Fukuoka, 802-0077, Japan.
Department of Pathology, Kitakyushu Municipal Medical Center, 2-1-1 Bashaku, Kokurakita-ku, Kitakyushu, Fukuoka, 802-0077, Japan.
Breast Cancer. 2018 Jul;25(4):470-478. doi: 10.1007/s12282-018-0847-7. Epub 2018 Feb 19.
Breast carcinoma arising in a benign fibroepithelial tumor is rare, and is usually discovered incidentally during examination of the breast mass.
We evaluated the clinicopathological features, treatment, and prognosis of seven women with breast carcinomas within benign fibroepithelial tumors, diagnosed and treated at a single institution between 2011 and 2015.
Seven women, aged 21-64 years, visited our hospital complaining of a breast mass detected by self-checking or screening examination. All patients had well-demarcated movable breast masses. Ultrasonography showed circumscribed masses suggesting benign tumors in all cases, and mammography revealed well-defined, high-density masses, with or without calcification. The masses progressed in two patients. A preoperative histological diagnosis of carcinoma was made following needle biopsy in four patients. Tumorectomy, breast-conserving surgery, and mastectomy were performed in three, two, and two patients, respectively. One patient underwent lymph node dissection and another underwent sentinel node biopsy. Histologically, the masses were diagnosed as invasive ductal carcinoma, ductal carcinoma in situ or lobular carcinoma in situ, arising in a benign phyllodes tumor, fibroadenoma, or fibroadenomatoid mastopathy. Lymph node metastasis was detected in two patients. There was no recurrence in any of the patients.
Although a carcinoma within a preexisting benign fibroepithelial tumor is extremely rare, it is important to be aware of the possibility of invasive and metastatic disease.
良性纤维上皮肿瘤中发生的乳腺癌很少见，通常是在检查乳房肿块时偶然发现的。
我们评估了 7 名在 2011 年至 2015 年在一家机构就诊并接受治疗的患有良性纤维上皮肿瘤内乳腺癌的女性的临床病理特征、治疗和预后。
7 名年龄在 21-64 岁的女性因自检或筛查检查发现乳房肿块就诊。所有患者均有边界清楚的可移动乳房肿块。超声检查显示所有病例均为边界清楚的肿块，提示为良性肿瘤，而乳房 X 线摄影显示边界清楚的高密度肿块，伴有或不伴有钙化。2 例肿块进展。4 例患者经针吸活检后术前组织学诊断为癌。3 例患者行肿瘤切除术，2 例患者行保乳手术，2 例患者行乳房切除术。1 例患者行淋巴结清扫术，另 1 例患者行前哨淋巴结活检术。组织学上，这些肿块被诊断为良性叶状肿瘤、纤维腺瘤或纤维腺瘤样乳腺病中发生的浸润性导管癌、导管原位癌或小叶原位癌。2 例患者发生淋巴结转移。所有患者均无复发。
虽然良性纤维上皮肿瘤中存在的癌极为罕见，但了解发生浸润性和转移性疾病的可能性很重要。
