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77溴-司哌罗宁在精神分裂症患者和对照组纹状体中的摄取情况。

Uptake of 77Br-spiperone in the striata of schizophrenic patients and controls.

作者信息

Crawley J C, Crow T J, Johnstone E C, Oldland S R, Owen F, Owens D G, Smith T, Veall N, Zanelli G D

出版信息

Nucl Med Commun. 1986 Aug;7(8):599-607. doi: 10.1097/00006231-198608000-00006.

DOI:10.1097/00006231-198608000-00006
PMID:2946010
Abstract

Twelve patients with a diagnosis of schizophrenia and thirteen control subjects were injected with 77Br-bromospiperone and scanned using single photon emission tomography after 16 h. Although a statistically significant increase in patients by comparison with controls could be demonstrated, wide variations in specific activity of the ligand preclude a firm conclusion. In two patients but no controls an asymmetry in striatal uptake was noted, the uptake on the left being less than that on the right.

摘要

12名精神分裂症患者和13名对照受试者被注射了77Br-溴哌啶醇，并在16小时后使用单光子发射断层扫描进行扫描。尽管与对照组相比，患者体内有统计学上的显著增加，但配体比活性的广泛差异使得无法得出确切结论。在两名患者中发现纹状体摄取存在不对称，但对照组中未发现，左侧摄取低于右侧。

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