Martinot J L, Peron-Magnan P, Huret J D, Mazoyer B, Baron J C, Boulenger J P, Loc'h C, Maziere B, Caillard V, Loo H
Service Hospitalier Fréderic Joliot, Département de Biologie, Commissariat à l'Energie Atomique, Orsay, France.
Am J Psychiatry. 1990 Jan;147(1):44-50. doi: 10.1176/ajp.147.1.44.
Striatal D2 dopaminergic receptors of 12 drug-free schizophrenic patients and 12 normal subjects were investigated with positron emission tomography and [76Br]bromospiperone. Patients were classified according to DSM-III criteria, and their clinical symptoms were rated according to Andreasen's negative and positive symptom scales. The ratio of striatal to cerebellar radioactivity was taken as an index of striatal D2 dopamine receptor density. There was no significant difference between the control subjects and the overall schizophrenic group and no significant relationship between this index and the symptom ratings. However, state-dependent variables could partly account for the striatal D2 receptor density variability.
利用正电子发射断层扫描和[76Br]溴螺哌隆对12名未服用药物的精神分裂症患者及12名正常受试者的纹状体D2多巴胺能受体进行了研究。患者根据《精神疾病诊断与统计手册》第三版标准进行分类，其临床症状根据安德烈亚森阴性和阳性症状量表进行评分。纹状体与小脑放射性的比值被用作纹状体D2多巴胺受体密度的指标。对照组与整个精神分裂症组之间无显著差异，该指标与症状评分之间也无显著关系。然而，状态依赖性变量可部分解释纹状体D2受体密度的变异性。
