Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, 02912, USA.
Center for Alcohol and Addiction Studies, Department of Behavioral and Social Sciences, Brown University, Providence, RI, USA.
Psychopharmacology (Berl). 2018 Jun;235(6):1625-1634. doi: 10.1007/s00213-018-4843-6. Epub 2018 Feb 20.
The role of norepinephrine (NE) in the development of alcohol use disorder (AUD) has been studied over the past several decades. However, the NE system has been largely ignored for many years as a potential target for medication development for AUD. More recently, preclinical and clinical studies have demonstrated the potential value of targeting NE signaling for developing new pharmacological treatments for AUD. This review contributes to a special issue of Psychopharmacology focused on promising targets for alcohol addiction. Specifically, this review coalesces preclinical and clinical neuroscience that re-evaluate the noradrenergic system, and in particular the alpha-1 receptor, as a potential target for AUD.
在过去的几十年里，去甲肾上腺素（NE）在酒精使用障碍（AUD）发展中的作用一直是研究的热点。然而，多年来，NE 系统作为 AUD 药物开发的潜在靶点在很大程度上被忽视了。最近，临床前和临床研究表明，针对 NE 信号的潜在价值，为开发 AUD 的新的药理学治疗方法提供了可能。这篇综述为《精神药理学》杂志的一个特刊做出了贡献，该特刊专注于有前途的酒精成瘾靶点。具体来说，这篇综述汇集了临床前和临床神经科学，重新评估了去甲肾上腺素系统，特别是 alpha-1 受体，作为 AUD 的一个潜在靶点。
