Department of Medical Biotechnology, Medical University of Lodz, Lodz, Poland.
BJOG. 2018 Oct;125(11):1379-1387. doi: 10.1111/1471-0528.15172. Epub 2018 Mar 23.
The transcription factor nuclear factor kappa B (NFκB) controls the expression of over 400 genes, some of which are associated with reproductive events. During implantation, immune cells accumulate in the maternal-fetal interface; they secrete inflammatory mediators under the control of NFĸB, the level of which also rises. NFĸB is then downregulated to maintain gestation, but its level rises again before birth to manage prostaglandin, cytokine, and chemokine synthesis, and to stimulate uterine contraction. This review summarises the current state of knowledge about NFκB and its role in the molecular regulation of processes related to pregnancy development.
This review examines the current state of knowledge about role of NFκB in the development of pregnancy.
转录因子核因子 kappa B（NFκB）控制着超过 400 个基因的表达，其中一些与生殖事件有关。在着床过程中，免疫细胞在母胎界面聚集；在 NFκB 的控制下，它们分泌炎症介质，NFκB 的水平也随之升高。然后，NFκB 被下调以维持妊娠，但在分娩前再次升高，以管理前列腺素、细胞因子和趋化因子的合成，并刺激子宫收缩。这篇综述总结了目前关于 NFκB 及其在与妊娠发育相关的分子调控过程中的作用的知识状况。
这篇综述检查了目前关于 NFκB 在妊娠发展中的作用的知识状况。
