在孕早期，性激素结合球蛋白水平可能预测妊娠糖尿病的发生。
Sex hormone-binding globulin levels during the first trimester may predict gestational diabetes mellitus development.
机构信息
Department of Endocrinology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, PR China.
Department of Endocrinology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, PR China.
出版信息
Biomark Med. 2018 Mar;12(3):239-244. doi: 10.2217/bmm-2016-0030. Epub 2018 Feb 20.
AIM
To investigate the association of sex hormone-binding globulin (SHBG) levels of early pregnancy with gestational diabetes mellitus (GDM) development.
METHODS
A total of 443 pregnant women during the first trimester (<12 weeks) were enrolled. SHBG levels were measured.
RESULTS
SHBG level was lower in women with GDM than in women without GDM (93.9 ± 34.4 nmol/l vs 128.1 ± 60.3 nmol/l; p = 0.001). Among the four quartiles (Q1-Q4) according to SHBG levels, GDM incidences were 17.5, 27.8, 5.1 and 2.6%, respectively. No differences were found between Q1 and Q2, and Q3 and Q4. The risk of developing GDM among women in Q1 + Q2 compared with Q3 + Q4 was 5.7.
CONCLUSION
Decreased SHBG concentrations during the first trimester may predict GDM development.
目的
探讨早孕期性激素结合球蛋白（SHBG）水平与妊娠期糖尿病（GDM）发展的关系。
方法
共纳入 443 例孕早期（<12 周）孕妇，检测 SHBG 水平。
结果
GDM 组的 SHBG 水平低于非 GDM 组（93.9±34.4 nmol/L 比 128.1±60.3 nmol/L；p=0.001）。根据 SHBG 水平分为四个四分位数（Q1-Q4），GDM 的发生率分别为 17.5%、27.8%、5.1%和 2.6%。Q1 与 Q2 之间、Q3 与 Q4 之间无差异。与 Q3+Q4 相比，Q1+Q2 中发生 GDM 的风险为 5.7。
结论
早孕期 SHBG 浓度降低可能预测 GDM 的发展。
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