Progetto ONCONET2.0 - Linea progettuale 14 per l'implementazione della prevenzione e diagnosi precoce del tumore alla prostata e testicolo - Regione Campania, Italy.
Eur Rev Med Pharmacol Sci. 2018 Feb;22(3):645-661. doi: 10.26355/eurrev_201802_14290.
In this review, we focused our attention on Quality of Life (QoL) of testicular cancer survivors (TCSs), in general and in the most relevant areas. Several key findings have been highlighted in our review.
PubMed, MEDLINE and PsycINFO databases were consulted to find published studies, from 1980 to May 2017, that met our inclusion criteria.
The majority of studies investigated older adult TCSs, while few studies on adolescent and young adult patients were available. Many studies indicate that health-related QoL (HRQoL) is similar among the TCSs and the general population. Even if QoL deteriorates so clear at the time of diagnosis and throughout treatment, afterward returns to normal levels, as defined by the matched controls. However, there are numerous chronic conditions consequent to diagnosis and treatment of testicular cancer that plague survivors and affect QoL, like Raynaud-like phenomena, peripheral neuropathy, fatigue, anxiety, sexual, fertility and body image problems. Even if these problems can have no effects on the measures of global QoL, they have an impact on the quality of life. Differences between TCSs with and without a partner bring to different outcomes in the adjustments to cancer.
It is necessary to identify TCSs with higher risks of poorer QoL outcomes, to focus interventions on the areas with the greatest impairments. Further researches should consider the effects of testicular cancer on the impaired areas, collecting more data to better identify survivor's needs and consequent interventions, with a special focus on adolescent and young adult TCSs. Other works are requested on therapies, preventive and ameliorative, to reduce chronic side effects of testicular cancer treatment.
在本次综述中，我们关注了睾丸癌幸存者（TCSs）的总体生活质量（QoL）和相关领域。我们在综述中强调了几个关键发现。
我们检索了 PubMed、MEDLINE 和 PsycINFO 数据库，以查找符合我们纳入标准的、发表于 1980 年至 2017 年 5 月的研究。
大多数研究都调查了老年 TCSs，而关于青少年和年轻成年患者的研究较少。许多研究表明，TCSs 的健康相关生活质量（HRQoL）与一般人群相似。即使在诊断和治疗期间 QoL 明显恶化，随后也会恢复到正常水平，与匹配的对照组定义的正常水平相同。然而，由于诊断和治疗睾丸癌而导致的许多慢性疾病会困扰幸存者并影响 QoL，如雷诺现象、周围神经病、疲劳、焦虑、性功能、生育和身体形象问题。即使这些问题对整体 QoL 的衡量没有影响，它们也会对生活质量产生影响。有伴侣和没有伴侣的 TCSs 之间的差异会导致他们对癌症的调整产生不同的结果。
有必要确定 QoL 结果较差的 TCSs，以便将干预措施集中在受影响最大的领域。进一步的研究应考虑睾丸癌对受损领域的影响，收集更多数据以更好地确定幸存者的需求和随后的干预措施，特别关注青少年和年轻成年 TCSs。需要开展更多关于治疗、预防和改善的研究，以减少睾丸癌治疗的慢性副作用。
