Gandelman Erin, Petrakis Ismene, Kachadourian Lorig, Ralevski Elizabeth
a Department of Psychiatry , Yale University School of Medicine , New Haven , Connecticut , USA.
b Department of Veterans Affairs , VA Connecticut Healthcare System , West Haven , Connecticut , USA.
J Dual Diagn. 2018 Apr-Jun;14(2):96-101. doi: 10.1080/15504263.2018.1434264. Epub 2018 Apr 25.
Negative affect intensity and hostility have both been implicated in alcohol use disorders (AUD) and posttraumatic stress disorder (PTSD) when they occur separately, but neither have been compared or explored among those with comorbid AUD and PTSD. This study is a secondary analysis designed to compare levels of negative affect intensity and hostility among those with AUD to those with comorbid AUD and PTSD.
Participants (n = 113) were recruited from the placebo-controlled groups of two distinct 12-week clinical trials (NCT00342563 and NCT00744055). The Short Affect Intensity Scale and Buss-Durkee Hostility Inventory were administered at weeks 0, 4, 8, and 12 to all study participants to assess negative affect intensity and hostility levels, respectively.
Individuals with comorbid AUD and PTSD showed significantly higher levels of negative affect intensity and hostility than individuals with AUD only. These levels remained relatively stable over the course of the study in spite of all study participants showing clinically significant improvements in AUD severity and PTSD symptomatology (for those with dual diagnosis).
Our results indicate that individuals with comorbid AUD and PTSD have higher levels of negative affect and higher levels of hostility compared to individuals with AUD alone. In addition, these heightened levels of negative affect intensity and hostility appear to function somewhat independently of diagnosis severity and symptomatology improvement. To our knowledge, this is the first study to compare negative affect intensity and hostility levels between individuals with AUD alone and those with comorbid AUD and PTSD.
消极情感强度和敌意各自与酒精使用障碍（AUD）和创伤后应激障碍（PTSD）有关，但其在共病AUD和PTSD患者中未被比较或探讨。本研究是一项二次分析，旨在比较AUD患者与共病AUD和PTSD患者的消极情感强度和敌意水平。
参与者（n = 113）从两项不同的12周临床试验（NCT00342563和NCT00744055）的安慰剂对照组中招募。在第0、4、8和12周，对所有研究参与者分别使用简短情感强度量表和布斯-杜克敌意量表来评估消极情感强度和敌意水平。
共病AUD和PTSD的个体比仅患有AUD的个体表现出显著更高的消极情感强度和敌意水平。尽管所有研究参与者在AUD严重程度和PTSD症状（对于双重诊断者）方面都有临床显著改善，但在研究过程中这些水平保持相对稳定。
我们的结果表明，与仅患有AUD的个体相比，共病AUD和PTSD的个体具有更高的消极情感水平和更高的敌意水平。此外，这些增强的消极情感强度和敌意水平似乎在一定程度上独立于诊断严重程度和症状改善而发挥作用。据我们所知，这是第一项比较仅患有AUD的个体与共病AUD和PTSD的个体之间消极情感强度和敌意水平的研究。
