Tosk J, Lau B H, Myers R C, Torrey R
Biochem Biophys Res Commun. 1986 Nov 14;140(3):1086-92. doi: 10.1016/0006-291x(86)90746-1.
The phototoxicity of hematoporphyrin derivative (Hpd) to murine bladder tumor (MBT-2) cells was studied in vitro. It was observed that selenium in the form of sodium selenite enhanced Hpd-sensitized photodamage in MBT-2 cells under conditions where selenite alone was non-toxic. Sodium selenite enhanced the fluorescence emission of Hpd and augmented the Hpd-sensitized photooxidation of tryptophan. The data suggest that sodium selenite is able to disaggregate Hpd, thereby enhancing Hpd-sensitized phototoxicity.
在体外研究了血卟啉衍生物（Hpd）对小鼠膀胱肿瘤（MBT-2）细胞的光毒性。观察到在亚硒酸钠单独无毒的条件下，亚硒酸钠形式的硒增强了Hpd对MBT-2细胞的光损伤作用。亚硒酸钠增强了Hpd的荧光发射，并增强了Hpd致敏的色氨酸光氧化。数据表明亚硒酸钠能够使Hpd解聚，从而增强Hpd致敏的光毒性。
