Effects of combined therapy with resveratrol, continuous and interval exercises on apoptosis, oxidative stress, and inflammatory biomarkers in the liver of old rats with non-alcoholic fatty liver disease.

CONTEXT

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder.

OBJECTIVE

Effects of combined therapy with resveratrol, interval and continuous exercises on oxidative stress, inflammation, and apoptosis in the liver of rats with NAFLD.

METHODS

NAFLD rats were organised in patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV groups.

RESULTS

Resveratrol supplementation alone or in combination with interval and continuous training significantly decreased malondialdehyde and TNF-α level (p < .05), while the levels of catalase; superoxide dismutase and IL-10 were significantly increased (p < .05). Although RSV alone significantly decreased the percentage of apoptotic cells (17.12%), its combination with interval (10.74%), and continuous (14.85%) exercise training demonstrated higher anti-apoptotic activity (p < .05).

CONCLUSIONS

Although resveratrol alone has an antioxidant, anti-apoptotic and anti-inflammatory properties, combined therapy with interval, and continuous training can be more effective to mitigate these abnormalities in NAFLD patients.