a Department of Exercise Physiology, Sari Branch , Islamic Azad University , Sari , Iran.
b Department of Anatomical Sciences, Faculty of Medical Sciences , Tarbiat Modares University , Tehran , Iran.
Arch Physiol Biochem. 2019 May;125(2):142-149. doi: 10.1080/13813455.2018.1441872. Epub 2018 Feb 20.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder.
Effects of combined therapy with resveratrol, interval and continuous exercises on oxidative stress, inflammation, and apoptosis in the liver of rats with NAFLD.
NAFLD rats were organised in patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise + RSV, and interval exercise + RSV groups.
Resveratrol supplementation alone or in combination with interval and continuous training significantly decreased malondialdehyde and TNF-α level (p < .05), while the levels of catalase; superoxide dismutase and IL-10 were significantly increased (p < .05). Although RSV alone significantly decreased the percentage of apoptotic cells (17.12%), its combination with interval (10.74%), and continuous (14.85%) exercise training demonstrated higher anti-apoptotic activity (p < .05).
Although resveratrol alone has an antioxidant, anti-apoptotic and anti-inflammatory properties, combined therapy with interval, and continuous training can be more effective to mitigate these abnormalities in NAFLD patients.
非酒精性脂肪性肝病（NAFLD）是最常见的慢性肝脏疾病。
研究白藜芦醇、间歇和连续运动联合治疗对非酒精性脂肪性肝病大鼠肝脏氧化应激、炎症和细胞凋亡的影响。
将非酒精性脂肪性肝病大鼠分为患者组、盐水组、白藜芦醇（RSV）组、连续运动组、间歇运动组、连续运动+RSV 组和间歇运动+RSV 组。
白藜芦醇单独或联合间歇和连续训练显著降低丙二醛和 TNF-α水平（p<0.05），而过氧化氢酶、超氧化物歧化酶和 IL-10 水平显著升高（p<0.05）。虽然 RSV 单独治疗可显著降低凋亡细胞的百分比（17.12%），但其与间歇（10.74%）和连续（14.85%）运动训练联合治疗显示出更高的抗凋亡活性（p<0.05）。
虽然白藜芦醇单独具有抗氧化、抗凋亡和抗炎作用，但联合间歇和连续训练可能更有效地减轻非酒精性脂肪性肝病患者的这些异常。
