阿尔茨海默病中行为重复效应的保留与后皮质神经机制改变有关。
Spared behavioral repetition effects in Alzheimer's disease linked to an altered neural mechanism at posterior cortex.
作者信息
Broster Lucas S, Li Juan, Wagner Benjamin, Smith Charles D, Jicha Gregory A, Schmitt Frederick A, Munro Nancy, Haney Ryan H, Jiang Yang
机构信息
a Department of Behavioral Science , University of Kentucky College of Medicine , Lexington , KY , USA.
b Department of Psychiatry , University of California , San Francisco , CA , USA.
出版信息
J Clin Exp Neuropsychol. 2018 Oct;40(8):761-776. doi: 10.1080/13803395.2018.1430230. Epub 2018 Feb 20.
OBJECTIVE
Individuals with dementia of the Alzheimer type (AD) classically show disproportionate impairment in measures of working memory, but repetition learning effects are relatively preserved. As AD affects brain regions implicated in both working memory and repetition effects, the neural basis of this discrepancy is poorly understood. We hypothesized that the posterior repetition effect could account for this discrepancy due to the milder effects of AD at visual cortex.
METHOD
Participants with early AD, amnestic mild cognitive impairment (MCI), and healthy controls performed a working memory task with superimposed repetition effects while electroencephalography was collected to identify possible neural mechanisms of preserved repetition effects.
RESULTS
Participants with AD showed preserved behavioral repetition effects and a change in the posterior repetition effect.
CONCLUSION
Visual cortex may play a role in maintained repetition effects in persons with early AD.
目的
阿尔茨海默型痴呆（AD）患者通常在工作记忆测量中表现出不成比例的损害，但重复学习效应相对保留。由于AD会影响与工作记忆和重复效应相关的脑区，这种差异的神经基础尚不清楚。我们假设后部重复效应可以解释这种差异，因为AD对视觉皮层的影响较轻。
方法
早期AD患者、遗忘型轻度认知障碍（MCI）患者和健康对照者进行一项叠加重复效应的工作记忆任务，同时收集脑电图以确定保留重复效应的可能神经机制。
结果
AD患者表现出保留的行为重复效应和后部重复效应的变化。
结论
视觉皮层可能在早期AD患者维持重复效应中起作用。
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