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用于抗癌药物递送的前沿蛋白质和碳水化合物基材料。

Cutting Edge Protein and Carbohydrate-Based Materials for Anticancer Drug Delivery.

作者信息

Ahmad Rasheed, Deng Yan, Singh Ravina, Hussain Mubashir, Shah Muhammad Ali Abdullah, Elingarami Sauli, He Nongyue, Sun Yueming

出版信息

J Biomed Nanotechnol. 2018 Jan 1;14(1):20-43. doi: 10.1166/jbn.2018.2476.

Abstract

Materials derived from biological sources not only offer biocompatibility but also adjust with the disease for elongated treatments and more effective therapies. These materials can be utilized as building blocks to construct state of the art drug delivery vehicles like nanoparticles, hydrogels, and nanofibers capable of dramatically enhancing the therapeutic efficiency in cancer treatment. New emerging trends in drug delivery design are constantly reported in recent literature using carbohydrates like cellulose, chitosan, and alginate and proteins like albumin, collagen, gelatin, and zein. In addition, drug vehicles with combination of carbohydrates and proteins have proved extremely effective. This article reviews carbohydrate and protein-based materials in fabrication of cutting edge drug delivery systems and clarifies their future impact in therapeutic methods to cure cancer.

摘要

源自生物源的材料不仅具有生物相容性,还能根据疾病情况进行调整,以实现长期治疗和更有效的疗法。这些材料可用作构建纳米颗粒、水凝胶和纳米纤维等先进药物递送载体的基础材料,这些载体能够显著提高癌症治疗的疗效。近期文献不断报道药物递送设计中的新趋势,如使用纤维素、壳聚糖和藻酸盐等碳水化合物以及白蛋白、胶原蛋白、明胶和玉米醇溶蛋白等蛋白质。此外,碳水化合物和蛋白质组合的药物载体已被证明极为有效。本文综述了用于制造前沿药物递送系统的基于碳水化合物和蛋白质的材料,并阐明了它们在癌症治疗方法中的未来影响。

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