Grant J B, Ahmed S R, Shalet S M, Costello C B, Howell A, Blacklock N J
Br J Urol. 1986 Oct;58(5):539-44. doi: 10.1111/j.1464-410x.1986.tb05463.x.
Diurnal profiles of circulating gonadotrophins and testosterone have been measured in patients with prostatic carcinoma on long-term treatment with the LHRH agonist analogue ICI 118630, which was administered either by subcutaneous daily injection or monthly injection of the depot preparation. These have been compared with profiles in patients who had undergone orchiectomy. Daily injection of the analogue induced a significant rise in the level of LH but this was not associated with a significant rise in circulating testosterone. There was no diurnal variation of LH or testosterone concentration in patients receiving the depot preparation and this did not differ in patients who were "mid-cycle" compared with those who were "end-cycle". The depot preparation did, however, induce significantly lower circulating levels of testosterone than did daily injection of the analogue and the levels were comparable with those achieved after orchiectomy.
对长期接受促性腺激素释放激素（LHRH）激动剂类似物ICI 118630治疗的前列腺癌患者的循环促性腺激素和睾酮的昼夜变化情况进行了测量。该类似物通过皮下每日注射或长效制剂每月注射给药。将这些结果与接受睾丸切除术的患者的情况进行了比较。每日注射该类似物会导致促黄体生成素（LH）水平显著升高，但这与循环睾酮水平的显著升高无关。接受长效制剂的患者中，LH或睾酮浓度没有昼夜变化，处于“周期中期”的患者与处于“周期末期”的患者之间也没有差异。然而，长效制剂诱导的循环睾酮水平明显低于每日注射类似物的情况，且这些水平与睾丸切除术后达到的水平相当。
