Srivastava Gitanjali, Buffington Cynthia
Department of Medicine, Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine, Boston, MA, 02118, USA.
The Center for Obesity Medicine, Florida Hospital Medical Group, Celebration, FL, 34747, USA.
Obes Surg. 2018 Aug;28(8):2241-2246. doi: 10.1007/s11695-018-3141-z.
Although bariatric surgery results in massive weight loss, weight regain over time up to as much as 25% is not uncommon. Weight regain in this population often leads to long-term weight loss failure and non-compliance in clinical follow-up and program recommendations.
We analyzed early weight outcomes at 3 and 6 months of 48 bariatric patients referred to an individualized, multidisciplinary medical management program at the Center for Obesity Medicine (COM) to address weight regain in 2015 and compared to a group of matched non-bariatric patients. The medical management center, under the direction of a medical obesity specialist and complementary to the surgical program and multidisciplinary team, addressed weight regain with intensive lifestyle (diet, activity, anti-stress therapy, behavioral counseling, sleep) and with medical intervention (one or more anti-obesity medications).
According to early findings, the average percentage post-operative weight regain of patients entering the weight management program was 20% above nadir and time since surgery averaged 6 years (range = 1 to 20 years) with a mean weight loss of - 2.3 kg after 3 months and - 4.4 kg at 6 months into the program. Individuals most successful with weight loss were those treated with anorexigenic pharmaceuticals. Weight and percent weight loss were significantly greater for the non-surgical than the surgical patients at 3 and 6 months (p < 0.05).
A medically supervised weight management program complementary to surgery is beneficial for the treatment of weight regain and may prove important in assisting the surgical patient achieve long-term weight loss success.
尽管减肥手术能带来显著的体重减轻,但随着时间推移,体重反弹高达25%的情况并不罕见。该人群的体重反弹常常导致长期减肥失败,以及临床随访和项目建议的依从性不佳。
我们分析了2015年转诊至肥胖医学中心(COM)个性化多学科医学管理项目以解决体重反弹问题的48例减肥患者在3个月和6个月时的早期体重结果,并与一组匹配的非减肥患者进行比较。该医学管理中心在医学肥胖专家的指导下,作为手术项目和多学科团队的补充,通过强化生活方式(饮食、运动、抗应激治疗、行为咨询、睡眠)和医学干预(一种或多种抗肥胖药物)来解决体重反弹问题。
根据早期研究结果,进入体重管理项目的患者术后体重反弹的平均百分比比最低点高20%,手术时间平均为6年(范围=1至20年),项目进行3个月后平均体重减轻-2.3千克,6个月时为-4.4千克。减肥最成功的个体是那些接受食欲抑制药物治疗的人。在3个月和6个月时,非手术患者的体重和体重减轻百分比显著高于手术患者(p<0.05)。
与手术互补的医学监督体重管理项目对治疗体重反弹有益,可能对帮助手术患者实现长期减肥成功具有重要意义。