São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, Clinical Analysis, Rodovia Araraquara Jaú, Km 01 - s/, Araraquara, São Paulo, Brazil.
São Paulo State University (UNESP), Institute of Chemistry, Araraquara, Biochemistry & Chemical Technology, Araraquara, São Paulo, Brazil.
Future Microbiol. 2018 Mar;13:359-367. doi: 10.2217/fmb-2017-0154. Epub 2018 Feb 21.
This work aimed to produce a membrane based on fluconazole-loaded natural rubber latex (NRL), and study their interaction, drug release and antifungal susceptibility against Candida albicans.
MATERIALS & METHODS: Fluconazole-loaded NRL membrane was obtained by casting method.
The Fourier Transform Infrared Spectroscopy showed no modifications either in NRL or fluconazole after the incorporation. Mechanical test presented low Young's modulus and high strain, indicating the membranes have sufficient elasticity for biomedical application. The bio-membrane was able to release the drug and inhibit the growth of C. albicans as demonstrated by disk diffusion and macrodilution assays.
The biomembrane was able to release fluconazole and inhibit the growth of C. albicans, representing a promising biomaterial for skin application.
本工作旨在制备一种载氟康唑的天然胶乳（NRL）膜，并研究其相互作用、药物释放以及对白色念珠菌的抗真菌药敏性。
采用浇注法制备载氟康唑的 NRL 膜。
傅里叶变换红外光谱显示，NRL 或氟康唑在掺入后均未发生变化。力学试验表明，材料具有较低的杨氏模量和较高的应变，表明该膜具有足够的弹性，适用于生物医学应用。生物膜能够释放药物并抑制白色念珠菌的生长，这一点通过药敏纸片扩散法和大剂量稀释法得到了证实。
该生物膜能够释放氟康唑并抑制白色念珠菌的生长，有望成为一种用于皮肤的生物材料。
