Microbiota-Host Interactions & Clostridia Research Group, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago, 8370035, Chile.
Laboratorio de Genética y Patogénesis Bacteriana, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas, Universidad Andres Bello, Santiago, 8370035, Chile.
Future Microbiol. 2018 Mar;13:469-482. doi: 10.2217/fmb-2017-0203. Epub 2018 Feb 21.
Clostridioides difficile (C. difficile) has become a pathogen of worldwide importance considering that epidemic strains are disseminated in hospitals of several countries, where community-acquired infections act as a constant source of new C. difficile strains into hospitals. Despite the advances in the treatment of infections, more effective therapies against C. difficile are needed but, at the same time, these therapies should be less harmful to the resident gastrointestinal microbiota. The purpose of this review is to present a description of issues associated to C. difficile infection, a summary of current therapies and those in developmental stage, and a discussion of potential combinations that may lead to an increased efficacy of C. difficile infection treatment.
艰难梭菌（C. difficile）已成为一种具有全球重要性的病原体，因为流行菌株在多个国家的医院中传播，而社区获得性感染则是医院中新的艰难梭菌菌株的不断来源。尽管在感染治疗方面取得了进展，但仍需要更有效的针对艰难梭菌的治疗方法，但同时，这些治疗方法对肠道常驻微生物群的危害也应较小。本综述的目的是介绍与艰难梭菌感染相关的问题描述、当前治疗方法和处于研发阶段的治疗方法的概述，并讨论可能导致艰难梭菌感染治疗效果提高的潜在联合治疗方法。
