NeuroCure Cluster of Excellence and NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany.
NeuroCure Cluster of Excellence and NeuroCure Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany/Department of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany/Experimental and Clinical Research Center, Charité - Universitätsmedizin Berlin, Berlin, Germany/Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Mult Scler. 2019 Apr;25(4):554-564. doi: 10.1177/1352458518758911. Epub 2018 Feb 21.
Since recent studies suggested a role of the striatum and prefrontal cortex for multiple sclerosis (MS)-related fatigue, we investigated resting-state functional connectivity alterations of striatal subdivisions and the dorsolateral prefrontal cortex (dlPFC).
Resting-state functional magnetic resonance imaging was acquired in 77 relapsing-remitting MS patients (38 fatigued (F-MS), 39 non-fatigued (NF-MS)) and 41 matched healthy controls (HC). Fatigue severity was assessed using the fatigue severity scale. Seed-based connectivity analyses were performed using subregions of the striatum and the dlPFC as regions of interest applying non-parametric permutation testing.
Compared to HC and NF-MS patients, F-MS patients showed reduced caudate nucleus and ventral striatum functional connectivity with the sensorimotor cortex (SMC) and frontal, parietal, and temporal cortex regions. Fatigue severity correlated negatively with functional connectivity of the caudate nucleus and ventral striatum with the SMC and positively with functional connectivity of the dlPFC with the rostral inferior parietal gyrus and SMC.
MS-related fatigue is associated with reduced functional connectivity between the striatum and sensorimotor as well as attention and reward networks, in which the ventral striatum might be a key integration hub. Together with increased connectivity between the dlPFC and sensory cortical areas, these connectivity alterations shed light on the mechanisms of MS-related fatigue.
由于最近的研究表明纹状体和前额叶皮层在多发性硬化症（MS）相关疲劳中起作用，我们研究了纹状体细分区域和背外侧前额叶皮层（dlPFC）的静息状态功能连接变化。
对 77 例复发缓解型 MS 患者（38 例疲劳（F-MS），39 例非疲劳（NF-MS））和 41 例匹配的健康对照者（HC）进行静息状态功能磁共振成像。使用疲劳严重程度量表评估疲劳严重程度。使用纹状体的亚区和 dlPFC 作为感兴趣区域进行种子相关连接分析，应用非参数置换检验。
与 HC 和 NF-MS 患者相比，F-MS 患者的尾状核和腹侧纹状体与感觉运动皮层（SMC）以及额叶、顶叶和颞叶皮层区域的功能连接减少。疲劳严重程度与尾状核和腹侧纹状体与 SMC 的功能连接呈负相关，与 dlPFC 与额下回和 SMC 的功能连接呈正相关。
MS 相关疲劳与纹状体与感觉运动以及注意和奖励网络之间的功能连接减少有关，其中腹侧纹状体可能是关键的整合枢纽。与 dlPFC 与感觉皮层区域之间的连接增加一起，这些连接变化揭示了 MS 相关疲劳的机制。
