Pogodina V V, Medvedeva G S
Acta Virol. 1978 Jul;22(4):270-7.
Interactions of Getah and Sindbis virus populations in mixed infections of 5 tissue systems were competitive or neutral. The type of interaction is regulated by the host cell and virus population density. On reproduction in mouse brains and SPEV cell cultures the mixed population exhibited antigenic markers of Getah virus; in Syrian hamster kidney and chick embryo cell cultures those of Sindbis virus; and in Chinese hamster kidney cell cultures the antigenic markers of both viruses. Mixed populations with monospecific antigenic characteristics contained genomes of both viruses detectable by the TC marker (dual spetrum of cytopathogenicity). Clonal analysis of such populations confirmed the occurrence of genome masking and demonstrated the formation of genotypically mixed particles. Possible mechanisms of the antigenic dominance of one virus and selective blocking of functions of the other virus are discussed.
在5种组织系统的混合感染中，盖塔病毒和辛德毕斯病毒群体之间的相互作用是竞争性的或中性的。相互作用的类型受宿主细胞和病毒群体密度的调节。在小鼠脑和SPEV细胞培养物中繁殖时，混合群体表现出盖塔病毒的抗原标记；在叙利亚仓鼠肾和鸡胚细胞培养物中表现出辛德毕斯病毒的抗原标记；而在中国仓鼠肾细胞培养物中则表现出两种病毒的抗原标记。具有单特异性抗原特征的混合群体包含两种病毒的基因组，可通过TC标记检测到（细胞病变双谱）。对这些群体的克隆分析证实了基因组掩盖的发生，并证明了基因型混合颗粒的形成。文中讨论了一种病毒抗原优势和另一种病毒功能选择性阻断的可能机制。
