Chair and Department of Pediatrics, Medical University of Silesia, School of Medicine with the Division of Dentistry, Poland, ul.3 Maja, 41-800 Zabrze, Poland.
Endokrynol Pol. 2018;69(2):128-134. doi: 10.5603/EP.a2018.0007. Epub 2018 Feb 21.
Patients with CF present numerous pathological conditions such as malnutrition, depletion of fat-free mass, metabolic disturbances (abnormal glucose metabolism, increased insulin resistance, chronic energy deficit, local and chronic inflammation), which could affect or be associated with altered adipokines concentration Material and Methods: We aimed in this study to investigate the levels of selected adipokines such as resistin, apelin, adiponectin to demonstrate their application as possible markers of inflammation.
Serum level of resistin was higher (p < 0.001) and adiponectin - lower (p=0.02) in CF children than in healthy children. There was no difference in serum apelin level between two examined groups. However, values of adiponectin/BMI and apelin/BMI ratios in CF did not differ significantly from controls. Higher values of resistin/BMI ratio in CF in comparison to controls were observed Serum resistin/adiponectin ratio was significantly higher in CF patients than in controls (p < 0.0001). Resistin/BMI ratio correlated negatively with FEV1 (R:-48,p < 0.043). Serum resistin/adiponectin ratio correlated negatively with FEV1/FVC (R:-49, p=0.04), Adipokines showed no correlation with BMI and BMI-SDS, glucose, total cholesterol, and LDL-, HDL-cholesterol, triglyceride serum levels. Spirometric parameters FEV1, FVC, VC correlated negatively with serum glucose levels (R: -0.55, p < 0.018; R: -0.65 p < 0.0025; R:-0.76, p < 0.0008 respectively). FEV1 and FVC correlated positively with BMI-SDS (R:0.58, p < 0.01; R:0.5, p < 0.036, respectively).
A significant increase in resistin concentration expressed also as resistin/BMI, and resistin/adiponectin ratios, observed in children with CF may suggests that this adipokine is involved in the inflammatory process underlying the disease and is related to worse spirometric parameters describing airways obstruction.
CF 患者存在多种病理状况，如营养不良、去脂体重减少、代谢紊乱（葡萄糖代谢异常、胰岛素抵抗增加、慢性能量不足、局部和慢性炎症），这些状况可能会影响或与改变的脂肪因子浓度有关。
本研究旨在调查抵抗素、脂联素等选定脂肪因子的水平，以证明其作为炎症标志物的应用。
CF 患儿血清抵抗素水平高于健康儿童（p<0.001），脂联素水平较低（p=0.02）。两组血清apelin 水平无差异。然而，CF 组的脂联素/BMI 和 apelin/BMI 比值与对照组无显著差异。与对照组相比，CF 中更高的抵抗素/BMI 比值观察到血清抵抗素/脂联素比值在 CF 患者中明显高于对照组（p<0.0001）。抵抗素/BMI 比值与 FEV1 呈负相关（R：-48，p<0.043）。血清抵抗素/脂联素比值与 FEV1/FVC 呈负相关（R：-49，p=0.04）。脂肪因子与 BMI 和 BMI-SDS、血糖、总胆固醇、LDL-、HDL-胆固醇、三酰甘油血清水平无相关性。肺功能参数 FEV1、FVC、VC 与血清葡萄糖水平呈负相关（R：-0.55，p<0.018；R：-0.65，p<0.0025；R：-0.76，p<0.0008）。FEV1 和 FVC 与 BMI-SDS 呈正相关（R：0.58，p<0.01；R：0.5，p<0.036）。
在 CF 患儿中观察到抵抗素浓度的显著增加，表现为抵抗素/BMI 和抵抗素/脂联素比值，这表明这种脂肪因子参与了疾病的炎症过程，并与更差的描述气道阻塞的肺功能参数有关。
