消防人员的 miRNA 变化。
MicroRNA Changes in Firefighters.
机构信息
Department of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona (Dr Jeong, Dr Griffin, Ms Dearmon-Moore, Ms Littau, Dr Burgess); Department of Occupational and Environmental Medicine, Graduate School of Medicine Dongguk University-Seoul, Dongguk University Ilsan Hospital, Goyang, Republic of Korea (Dr Jeong); Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona (Drs Zhou, Jacobs, Ms Zhai); Tucson Fire Department, Tucson, Arizona (Mr Gulotta, Mr Moore); WellAmerica, Tucson, Arizona (Dr Peate); University of Arizona Genetics Core, Arizona Research Laboratories, University of Arizona, Tucson, Arizona (Richt).
出版信息
J Occup Environ Med. 2018 May;60(5):469-474. doi: 10.1097/JOM.0000000000001307.
OBJECTIVES
Firefighters have elevated cancer incidence and mortality rates. MicroRNAs play prominent roles in carcinogenesis, but have not been previously evaluated in firefighters.
METHODS
Blood from 52 incumbent and 45 new recruit nonsmoking firefighters was analyzed for microRNA expression, and the results adjusted for age, obesity, ethnicity, and multiple comparisons.
RESULTS
Nine microRNAs were identified with at least a 1.5-fold significant difference between groups. All six microRNAs with decreased expression in incumbent firefighters have been reported to have tumor suppressor activity or are associated with cancer survival, and two of the three microRNAs with increased expression in incumbent firefighters have activities consistent with cancer promotion, with the remaining microRNA associated with neurological disease.
CONCLUSION
Incumbent firefighters showed differential microRNA expression compared with new recruits, providing potential mechanisms for increased cancer risk in firefighters.
目的
消防员的癌症发病率和死亡率较高。microRNAs 在肿瘤发生中起着重要作用，但尚未在消防员中进行评估。
方法
分析了 52 名在职和 45 名新招募的不吸烟消防员的血液中的 microRNA 表达情况，并根据年龄、肥胖、种族和多次比较进行了调整。
结果
确定了 9 种 microRNAs，它们在两组之间的差异至少有 1.5 倍。在职消防员中表达降低的 6 种 microRNAs 均具有肿瘤抑制活性或与癌症生存相关，在职消防员中表达增加的 3 种 microRNAs 中有 2 种与癌症促进活性一致，其余 microRNA 与神经系统疾病相关。
结论
与新招募的消防员相比，在职消防员表现出不同的 microRNA 表达，为消防员癌症风险增加提供了潜在的机制。
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