Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Department of Community, Environment and Policy, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
J Expo Sci Environ Epidemiol. 2021 Sep;31(5):900-912. doi: 10.1038/s41370-021-00306-8. Epub 2021 Feb 18.
Dysregulated microRNA (miRNA) expression could provide a mechanism linking firefighter exposure to increased cancer risk.
To determine if changes in longitudinal miRNA expression in firefighters are associated with occupational exposures.
Whole blood MiRNA was evaluated in 52 new recruits prior to live-fire training and 20-37 months later. Linear mixed effects models adjusted for age, ethnicity, BMI, and batch effects were used to determine associations separately for all fires and structure fires only between employment duration, cumulative fire-hours and fire-runs, and time since most recent fire with (1) nine a priori and (2) the full array of 799 miRNAs.
For multivariable models including all fires, two a priori miRNAs were associated with employment duration and four with time since most recent fire. For multivariable models restricted to structure fires, three a priori miRNAs were associated with employment duration and one with fire-runs. Additional miRNAs from the full array were associated with employment duration for all fires and/or structure fires. In general, tumor suppressive miRNAs decreased and oncogenic miRNAs increased with exposure.
Changes in miRNAs may serve as biomarkers of exposure effects and a mechanism for increased cancer risk in firefighters.
miRNA 表达失调可能为消防员接触增加与癌症风险增加之间的联系提供一种机制。
确定消防员纵向 miRNA 表达的变化是否与职业暴露有关。
在进行实弹训练之前和 20-37 个月后，对 52 名新招募的消防员的全血 miRNA 进行了评估。线性混合效应模型调整了年龄、种族、BMI 和批次效应，分别针对所有火灾和仅结构火灾，对就业持续时间、累计火灾小时数和火灾次数以及最近一次火灾后的时间进行了调整，与（1）九个先验 miRNA 和（2）799 个 miRNA 的全部数组之间存在关联。
对于包括所有火灾的多变量模型，两个先验 miRNA 与就业持续时间有关，四个 miRNA 与最近一次火灾后的时间有关。对于仅限于结构火灾的多变量模型，三个先验 miRNA 与就业持续时间有关，一个 miRNA 与火灾次数有关。来自全部数组的其他 miRNA 与所有火灾和/或结构火灾的就业持续时间有关。一般来说，肿瘤抑制性 miRNA 随着暴露而减少，致癌 miRNA 随着暴露而增加。
miRNA 的变化可能作为暴露效应的生物标志物，并为消防员癌症风险增加提供一种机制。
