Kloosterboer H J, van Wayjen R G, van den Ende A
Contraception. 1986 Aug;34(2):135-44. doi: 10.1016/0010-7824(86)90066-1.
The effects of the monophasic oral contraceptive preparation desogestrel plus ethinyloestradiol (EE) and triphasic levonorgestrel plus EE on lipid metabolism were compared. Sixteen young healthy female volunteers received monophasic desogestrel plus EE (21 X 150/30), whereas eighteen women received triphasic levonorgestrel plus EE (6 X 50/30 + 5 X 75/40 + 10 X 125/30) for six consecutive cycles. The lipid composition of the various lipoprotein fractions was estimated after separation in a density gradient by ultracentrifugation. In addition, the apolipoproteins A-I and B were assessed. HDL-cholesterol (precipitation method), HDL-2 cholesterol, HDL-2 phospholipids and the ratio apolipoprotein A-I to apolipoprotein B were significantly higher in the monophasic desogestrel group than in the triphasic levonorgestrel group after three and six treatment cycles. HDL-cholesterol (gradient), HDL-phospholipids (gradient), HDL-3 phospholipids and apolipoprotein A-I were only significantly higher after six treatment cycles. No differences between the groups were observed for the other lipid variables studied including triglycerides and VLDL-triglycerides.
比较了单相口服避孕药去氧孕烯加炔雌醇（EE）和三相左炔诺孕酮加EE对脂质代谢的影响。16名年轻健康女性志愿者连续六个周期服用单相去氧孕烯加EE（21×150/30），而18名女性连续六个周期服用三相左炔诺孕酮加EE（6×50/30 + 5×75/40 + 10×125/30）。通过超速离心在密度梯度中分离后，估计各种脂蛋白组分的脂质组成。此外，还评估了载脂蛋白A-I和B。在三个和六个治疗周期后，单相去氧孕烯组的高密度脂蛋白胆固醇（沉淀法）、HDL-2胆固醇、HDL-2磷脂以及载脂蛋白A-I与载脂蛋白B的比值显著高于三相左炔诺孕酮组。高密度脂蛋白胆固醇（梯度法）、高密度脂蛋白磷脂（梯度法）、HDL-3磷脂和载脂蛋白A-I仅在六个治疗周期后显著升高。在研究的其他脂质变量（包括甘油三酯和极低密度脂蛋白甘油三酯）方面，未观察到两组之间存在差异。
