Wang Lianwei, Luo Runlan, Xiong Zuming, Xu Jinming, Fang Dengyang
Department of General Surgery, Fuling Central Hospital of Chongqing City, Chongqing Department of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Medicine (Baltimore). 2018 Feb;97(8):e9986. doi: 10.1097/MD.0000000000009986.
Pleomorphic liposarcoma (PLS), is a rare subtype of liposarcoma, and is considered to be of the highest malignancy grade.
We aimed to analyze the clinical features, diagnosis, treatment, and recurrence of the 6 cases of PLS.
Six cases with confirmed pathological PLS presented at out hospital from January 2003 to January 2017. The postoperative pathology of 5 cases confirmed PLS, and the other was confirmed as PLS with well-differentiated liposarcoma.
All 6 patients underwent complete tumor resection at the time of the first definite diagnosis, and one of them had underwent 3 cycles of chemotherapy treatment.
There were 4 cases with local recurrence and surgery was repeated after the first radical excision. One case was not recurrent after 27 months post-operation, and the other was lost. The shortest recurrence time of all of these cases was 4 months, and the longest was 29 months after the first radical surgery.
PLS is a rare and high-grade malignancy with high recurrence, poor prognosis, and its treatment is still highly controversial. More studies are required to determine the appropriate treatment and therapeutic strategies to improve the survival rate of patients with PLS, as the disease is associated with frequent relapse.
多形性脂肪肉瘤（PLS）是脂肪肉瘤的一种罕见亚型，被认为是恶性程度最高的类型。
我们旨在分析6例多形性脂肪肉瘤患者的临床特征、诊断、治疗及复发情况。
2003年1月至2017年1月，我院共收治6例经病理确诊的多形性脂肪肉瘤患者。5例患者术后病理确诊为多形性脂肪肉瘤，另1例确诊为多形性脂肪肉瘤合并高分化脂肪肉瘤。
所有6例患者在首次明确诊断时均接受了肿瘤完整切除，其中1例患者接受了3个周期的化疗。
4例患者出现局部复发，首次根治性切除后再次进行了手术。1例患者术后27个月未复发，另1例失访。所有这些病例中，首次根治性手术后最短复发时间为4个月，最长为29个月。
多形性脂肪肉瘤是一种罕见的高等级恶性肿瘤，复发率高，预后差，其治疗仍存在很大争议。由于该疾病经常复发，需要更多的研究来确定合适的治疗方法和治疗策略，以提高多形性脂肪肉瘤患者的生存率。
