Kelly M A, Campbell J, Sheahan J, Murphy P
National University of Ireland, Galway.
The Galway Clinic.
Ir Med J. 2017 Dec 18;110(10):649.
Vitamin D is essential for bone health. We aimed to assess the vitamin D levels of patients undergoing total knee arthroplasty TKA). All TKA patients during a calendar year had their 25-hydroxyvitamin-D3 (25-OH-D3) assay levels assessed pre and post operatively. A control group comprising of patients admitted for 1-day general medical assessment was recruited. Usage of supplements containing Vitamin D was recorded for both groups. There was no evidence of a difference in Vitamin D levels between the TKA group and the control group (p=0.19). Just over 40% of patients had insufficient levels of vitamin D in the TKA group (50 nmol/L cut off). There was a statistically significant drop in vitamin D levels post operatively (p=0.0001). Supplements were protective against insufficiency post operatively (p=0.0005, OR 6.0985). This study documents a high prevalence of vitamin D insufficiency in patients undergoing TKA surgery. Our results suggest a consumption of 25-OH-D3 as part of the surgical insult.
维生素D对骨骼健康至关重要。我们旨在评估接受全膝关节置换术（TKA）患者的维生素D水平。对一历年中的所有TKA患者在术前和术后进行了25-羟基维生素D3（25-OH-D3）检测水平评估。招募了一个由因进行为期1天的普通医学评估而入院的患者组成的对照组。记录了两组中含维生素D补充剂的使用情况。没有证据表明TKA组和对照组之间的维生素D水平存在差异（p = 0.19）。TKA组中略多于40%的患者维生素D水平不足（临界值为50 nmol/L）。术后维生素D水平有统计学意义的下降（p = 0.0001）。补充剂对术后维生素D不足有预防作用（p = 0.0005，比值比6.0985）。本研究记录了接受TKA手术患者中维生素D不足的高患病率。我们的结果表明，作为手术损伤的一部分，25-OH-D3的消耗情况。
