Bencze János, Varkoly Gréta, Hortobágyi Tibor
Debreceni Egyetem, Általános Orvostudományi Kar, Patológiai Intézet, Neuropatológiai Tanszék, Debrecen.
Debreceni Egyetem, Klinikai Központ, Neurológiai Klinika, Debrecen.
Ideggyogy Sz. 2016 Jul 30;69(7-8):220-224. doi: 10.18071/isz.69.0220.
Meningiomas are one of the most frequent primary intracranial tumours, representing one-third of all intracranialneoplasms. The vast majority of meningiomas are histologically benign, but recurrence and progression is quite frequent. They occur usually between the 6th and 7th decade, the female/male ratio is 3:2. Although rare in pregnancy, when occurring, they can cause serious, life-threatening complications due to rapid growth and unfavourable localisation. There are two dominant hypothesis explaining rapid growth in pregnancy: the role of hormonal effects and hemodynamic changes. Several studies tested these theories but none provided unequivocal answer probably because the pathomechanism is complex and multifactorial. We provide an overview of the pathomechanism of meningiomas in pregnancy with emphasis on data obtained by advanced neuropathological, molecular biological, bioinformatic, imaging and epidemiological methods. A better understanding of the processes leading to meningioma development and growth in pregnancy will help us to design personalized therapy and reduce morbidity and mortality.
脑膜瘤是最常见的原发性颅内肿瘤之一，占所有颅内肿瘤的三分之一。绝大多数脑膜瘤在组织学上是良性的，但复发和进展相当常见。它们通常发生在60至70岁之间，女性与男性的比例为3:2。脑膜瘤在孕期罕见，但一旦发生，由于生长迅速和位置不佳，可导致严重的、危及生命的并发症。有两种主要假说来解释孕期脑膜瘤的快速生长：激素效应和血流动力学变化的作用。多项研究对这些理论进行了验证，但均未给出明确答案，这可能是因为发病机制复杂且具有多因素性。我们概述了孕期脑膜瘤的发病机制，重点介绍了通过先进的神经病理学、分子生物学、生物信息学、影像学和流行病学方法获得的数据。更好地了解孕期脑膜瘤发生和生长的过程将有助于我们设计个性化治疗方案，并降低发病率和死亡率。
