单次玻璃体内注射贝伐单抗后视盘新生血管的时间变化。

TIME COURSE OF CHANGES IN OPTIC DISK NEOVASCULARIZATION AFTER A SINGLE INTRAVITREAL BEVACIZUMAB INJECTION.

机构信息

Eye Research Center, Department of Ophthalmology, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Department of Ophthalmology, David Geffen School of Medicine, University of California-Los Angeles, California, and Doheny Eye Institute, Los Angeles, California.

出版信息

Retina. 2019 Jun;39(6):1149-1153. doi: 10.1097/IAE.0000000000002107.

DOI:10.1097/IAE.0000000000002107

PMID:29466258

Abstract

PURPOSE

To evaluate the longitudinal changes in optic disk neovascularization (NVD) after intravitreal bevacizumab injection using optical coherence tomography angiography.

METHODS

In this prospective, interventional, case series, eyes with NVD secondary to diabetic retinopathy were enrolled. En face optical coherence tomography angiographic images were obtained from the optic disks before and 3 hours, 6 hours, 24 hours, 7 days, and 30 days after intravitreal bevacizumab injection. The size and flow area of the neovascularization were measured by two graders.

RESULTS

Eleven eyes of 9 patients with a mean age of 52.11 ± 9.48 years were included. The reduction in the NVD size and flow area was statistically significant at 24 hours, 7 days, and 30 days after injections compared with the baseline measurements (all P < 0.05). The decremental regression in the NVD size and flow area continued during the study course. The changes were not statistically significant in 3-hour and 6-hour measurements (all P > 0.05).

CONCLUSION

In this study, statistically significant regression in the NVD size and flow area was observed as early as 24 hours after a single intravitreal bevacizumab injection, with a continued decreasing trend for at least a 1-month period.

摘要

目的

利用光相干断层扫描血管造影术评估玻璃体内注射贝伐单抗后视盘新生血管（NVD）的纵向变化。

方法

本前瞻性、干预性、病例系列研究纳入了继发于糖尿病视网膜病变的 NVD 患者的眼。在玻璃体内注射贝伐单抗前和 3 小时、6 小时、24 小时、7 天和 30 天后，从视盘获得了 NVD 的眼底光学相干断层扫描血管造影图像。两名分级员测量了新生血管的大小和血流面积。

结果

9 例患者的 11 只眼，平均年龄为 52.11±9.48 岁。与基线测量相比，注射后 24 小时、7 天和 30 天，NVD 大小和血流面积的减少具有统计学意义（均 P<0.05）。在研究过程中，NVD 大小和血流面积的递减性回归持续存在。在 3 小时和 6 小时测量时，变化无统计学意义（均 P>0.05）。