Khadamy Joobin, Abri Aghdam Kaveh, Falavarjani Khalil Ghasemi
Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):487-497. doi: 10.4103/jovr.jovr_57_18.
Optical coherence tomography angiography (OCTA) is a novel non-invasive imaging modality for 3-dimensional visualization of retinal and optic nerve capillary networks. In this article, a comprehensive review of relevant original articles in the PubMed database was performed using the search terms "diabetic retinopathy," "diabetic macular edema," "diabetes mellitus," and "optical coherence tomography angiography." OCTA was found to detect microvascular changes early in diabetes mellitus, even before they become clinically evident. Morphological and qualitative assessment of vascular changes can help to determine the pathophysiological processes, activity, treatment, and follow-up of diabetic retinopathy (DR). Vessel density and foveal avascular zone are the most investigated quantified indices shown to be early predictors of DR, correlated to DR severity and visual function, and useful in predicting response to treatment. OCTA has shown to be a promising alternative to fluorescein angiography in the management of DR. Further studies are warranted to determine the role of OCTA in the routine clinical management of DR.
光学相干断层扫描血管造影（OCTA）是一种用于视网膜和视神经毛细血管网络三维可视化的新型非侵入性成像方式。在本文中，使用搜索词“糖尿病性视网膜病变”、“糖尿病性黄斑水肿”、“糖尿病”和“光学相干断层扫描血管造影”对PubMed数据库中的相关原始文章进行了全面综述。研究发现，OCTA能够在糖尿病早期检测到微血管变化，甚至在这些变化出现临床症状之前。对血管变化的形态学和定性评估有助于确定糖尿病性视网膜病变（DR）的病理生理过程、活动情况、治疗方法及随访情况。血管密度和黄斑无血管区是研究最多的量化指标，被证明是DR的早期预测指标，与DR严重程度和视觉功能相关，并且有助于预测治疗反应。在DR的管理中，OCTA已被证明是荧光素血管造影的一种有前景的替代方法。有必要进行进一步研究以确定OCTA在DR常规临床管理中的作用。
