来自美国重症肌无力基金会注册登记处的重症肌无力患者的性别与生活质量
Gender and quality of life in myasthenia gravis patients from the myasthenia gravis foundation of America registry.
作者信息
Lee Ikjae, Kaminski Henry J, Xin Haichang, Cutter Gary
机构信息
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Department of Neurology, The George Washington University, Washington, DC, USA.
出版信息
Muscle Nerve. 2018 Feb 21. doi: 10.1002/mus.26104.
INTRODUCTION
Quality of life (QOL) has been poorly characterized among patients with myasthenia gravis (MG) other than assessments performed within the clinical setting.
METHODS
Patients age ≥ 18 years who were diagnosed with MG and registered with the MG patient registry between July 1, 2013, and June 30, 2016, were included. Demographic information, disease related history, and QOL were compared between men and women using multivariable analysis.
RESULTS
A total of 1,315 subjects (827 women) were included. Women were significantly younger, had a younger age at symptom onset, and were more likely to have thymoma and thymectomy. The 15-item Myasthenia Gravis Quality of Life scale (MG-QOL15) was significantly worse in women. MG-QOL15 score was comparable between women who had thymectomy and men with or without thymectomy.
DISCUSSION
QOL among MG patients is worse in women compared with men, but this disparity is eliminated in women who have undergone thymectomy. Muscle Nerve, 2018.
引言
除了在临床环境中进行的评估外，重症肌无力（MG）患者的生活质量（QOL）一直缺乏充分的特征描述。
方法
纳入2013年7月1日至2016年6月30日期间被诊断为MG并在MG患者登记处登记的年龄≥18岁的患者。使用多变量分析比较了男性和女性的人口统计学信息、疾病相关病史和生活质量。
结果
共纳入1315名受试者（827名女性）。女性明显更年轻，症状出现时的年龄更小，并且更有可能患有胸腺瘤和接受胸腺切除术。女性的15项重症肌无力生活质量量表（MG-QOL15）明显更差。接受胸腺切除术的女性与接受或未接受胸腺切除术的男性之间的MG-QOL15评分相当。
讨论
与男性相比，MG患者中女性的生活质量更差，但在接受胸腺切除术的女性中这种差异消除了。《肌肉与神经》，2018年。
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