残疾儿童和青少年的健康状态效用值：一项系统评价方案
Health state utility values among children and adolescents with disabilities: protocol for a systematic review.
作者信息
Kanya Lucy, Anokye Nana, Ryan Jennifer M
机构信息
Institute of Environment, Health and Societies, Brunel University London, London, UK.
Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
出版信息
BMJ Open. 2018 Feb 21;8(2):e019978. doi: 10.1136/bmjopen-2017-019978.
INTRODUCTION
Increasingly, assessment of healthcare technologies and interventions requires the assessment of both costs and utilities. Health state utility values (HSUVs) are measured using a range of generic and condition-specific measures. While reviews have identified that generic measures of HSUVs may lack validity in adults with conditions that result in physical disability, there is little information available on the methods used to obtain HSUVs in children and adolescents with disabilities. The objectives of this systematic review are to describe the methods used to obtain HSUVs, including mode of administration and psychometric properties, and provide summary statistics for HSUVs among children and adolescents with disabilities.
METHODS AND ANALYSIS
The following databases will be searched from inception for English-language studies of any design: PubMed, PsychInfo, Medline, Scopus, CINAHL Plus, Econlit and EMBASE databases. Two reviewers will independently screen titles, abstracts and full text articles for studies reporting HSUVs and/or data on the psychometric properties of preference-based measures for children and adolescents with disabilities aged up to 19 years. Two reviewers will independently extract data items including descriptors of the study methods and sample, instruments used to capture HSUVs, summary statistics for HSUVs and items relating to the quality of reporting. A descriptive summary of results from included studies and summary statistics for HSUVs will be presented. If sufficient data is identified, we will pool summary statistics for HSUVs according to the method used to obtain the HSUV using a random effects model. In addition, we will explore the determinants of the HSUVs using a meta-regression.
ETHICS AND DISSEMINATION
Ethical approval will not be required as no original data will be collected as part of this review. The completed review will be submitted for publication in a peer-reviewed journal and presentation at conferences.
PROSPERO REGISTRATION NUMBER
CRD42018086574.
引言
对医疗技术和干预措施的评估越来越需要同时评估成本和效用。健康状态效用值（HSUVs）通过一系列通用和特定疾病的测量方法来衡量。虽然综述已表明，在患有导致身体残疾疾病的成年人中，HSUVs的通用测量方法可能缺乏有效性，但关于残疾儿童和青少年获取HSUVs的方法，几乎没有可用信息。本系统综述的目的是描述获取HSUVs的方法，包括施测方式和心理测量特性，并提供残疾儿童和青少年HSUVs的汇总统计数据。
方法与分析
将从数据库建立之初开始搜索以下数据库，以查找任何设计的英文研究：PubMed、PsychInfo、Medline、Scopus、CINAHL Plus、Econlit和EMBASE数据库。两名评审员将独立筛选标题、摘要和全文文章，以查找报告HSUVs和/或19岁及以下残疾儿童和青少年基于偏好测量的心理测量特性数据的研究。两名评审员将独立提取数据项，包括研究方法和样本的描述符、用于获取HSUVs的工具、HSUVs的汇总统计数据以及与报告质量相关的项目。将呈现纳入研究结果的描述性总结和HSUVs的汇总统计数据。如果确定有足够的数据，我们将使用随机效应模型根据获取HSUV的方法汇总HSUVs的汇总统计数据。此外，我们将使用元回归探索HSUVs的决定因素。
伦理与传播
由于本综述不收集原始数据，因此无需伦理批准。完成的综述将提交给同行评审期刊发表，并在会议上展示。
PROSPERO注册号：CRD42018086574。
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