Sirtuin1-PPARγ 轴在胎盘发育和功能中的作用。
The role of Sirtuin1-PPARγ axis in placental development and function.
机构信息
Department of PathologyUniversity of California San Diego, La Jolla, California, USA.
Sanford Consortium for Regenerative MedicineUniversity of California San Diego, La Jolla, California, USA.
出版信息
J Mol Endocrinol. 2018 May;60(4):R201-R212. doi: 10.1530/JME-17-0315. Epub 2018 Feb 21.
Abstract
Placental development is important for proper growth and development of the fetus, as well as maternal well-being during pregnancy. Abnormal differentiation of placental epithelial cells, called trophoblast, is at the root of multiple pregnancy complications, including miscarriage, the maternal hypertensive disorder preeclampsia and intrauterine growth restriction. The ligand-activated nuclear receptor, PPARγ, and nutrient sensor, Sirtuin-1, both play a role in numerous pathways important to cell survival and differentiation, metabolism and inflammation. However, each has also been identified as a key player in trophoblast differentiation and placental development. This review details these studies, and also describes how various stressors, including hypoxia and inflammation, alter the expression or activity of PPARγ and Sirtuin-1, thereby contributing to placenta-based pregnancy complications.
摘要
胎盘发育对于胎儿的正常生长和发育以及孕妇在怀孕期间的健康都很重要。胎盘上皮细胞（称为滋养层细胞）的异常分化是多种妊娠并发症的根源，包括流产、孕妇高血压疾病子痫前期和宫内生长受限。配体激活的核受体 PPARγ 和营养传感器 Sirtuin-1 都在许多对细胞存活和分化、代谢和炎症很重要的途径中发挥作用。然而，它们也被确定为滋养层细胞分化和胎盘发育的关键参与者。本综述详细介绍了这些研究，还描述了各种应激源（包括缺氧和炎症）如何改变 PPARγ 和 Sirtuin-1 的表达或活性，从而导致以胎盘为基础的妊娠并发症。
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本文引用的文献
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