Akkaya Fırat Asuman, Alıcı Davutoğlu Ebru, Özel Aysegül, Fırtına Tuncer Serap, Yılmaz Nevin, Madazlı Rıza
Department of Medical Biochemistry, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Department of Obstetrics and Gynecology, Perinatology Clinic, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.
Ir J Med Sci. 2025 Feb;194(1):181-188. doi: 10.1007/s11845-024-03865-5. Epub 2025 Jan 14.
Sirtuins and FoxO1 are reported to be important in the pathophysiology of preeclampsia. This study aimed to investigate whether serum FoxO1 and SIRT2 concentrations differ between preeclampsia and normal pregnancy and also to compare these markers in early- and late-onset preeclampsia.
This cross-sectional study was conducted on 27 women with early-onset preeclampsia, 27 women with late-onset preeclampsia, and 26 healthy normotensive pregnant controls. Maternal serum levels of FoxO1 and SIRT2 were measured with the use of an enzyme-linked immunosorbent assay kit.
The mean maternal serum FoxO1 levels were significantly lower both in early-onset (9.1 ± 3.8 vs. 29.1 ± 3.2, p < 0.001) and late-onset preeclampsia (2.6 ± 1.6 vs. 29.1 ± 3.2, p < 0.001) than the normotensive pregnancies. The mean maternal serum FoxO1 level of late-onset preeclampsia was significantly lower than the early-onset preeclampsia group (2.6 ± 1.6 vs. 9.1 ± 3.8, p < 0.001). The mean maternal serum SIRT2 levels were significantly lower both in early-onset (4.5 ± 2.1 vs. 6.3 ± 0.9, p < 0.001) and late-onset preeclampsia (2.1 ± 0.6 vs. 6.3 ± 0.9, p < 0.001) than the healthy pregnancies.
FoxO1 and SIRT2 may be biomarkers for early detection of preeclampsia and potential therapeutic targets in the pathophysiology of preeclampsia.
据报道，沉默调节蛋白和叉头框蛋白O1（FoxO1）在子痫前期的病理生理学中具有重要作用。本研究旨在调查子痫前期患者与正常妊娠女性的血清FoxO1和沉默调节蛋白2（SIRT2）浓度是否存在差异，并比较早发型和晚发型子痫前期患者的这些标志物。
本横断面研究纳入了27例早发型子痫前期患者、27例晚发型子痫前期患者和26例血压正常的健康孕妇作为对照。采用酶联免疫吸附测定试剂盒测量孕妇血清中FoxO1和SIRT2的水平。
早发型子痫前期患者（9.1±3.8 vs. 29.1±3.2，p<0.001）和晚发型子痫前期患者（2.6±1.6 vs. 29.1±3.2，p<0.001）的母体血清FoxO1平均水平均显著低于血压正常的妊娠女性。晚发型子痫前期患者的母体血清FoxO1平均水平显著低于早发型子痫前期组（2.6±1.6 vs. 9.1±3.8，p<0.001）。早发型子痫前期患者（4.5±2.1 vs. 6.3±0.9，p<0.001）和晚发型子痫前期患者（2.1±0.6 vs. 6.3±0.9，p<0.001）的母体血清SIRT2平均水平均显著低于健康妊娠女性。
FoxO1和SIRT2可能是子痫前期早期检测的生物标志物以及子痫前期病理生理学中的潜在治疗靶点。
