在携带因子V莱顿突变的个体中，体内凝血酶生成及随后的活化蛋白C形成增加。 - Suppr

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超能文献

In vivo thrombin generation and subsequent APC formation are increased in factor V Leiden carriers.

作者信息

Rühl Heiko, Winterhagen Franziska Isabelle, Berens Christina, Müller Jens, Oldenburg Johannes, Pötzsch Bernd

机构信息

Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Bonn, Germany.

出版信息

Blood. 2018 Mar 29;131(13):1489-1492. doi: 10.1182/blood-2017-12-823831. Epub 2018 Feb 21.

DOI:10.1182/blood-2017-12-823831

PMID:29467181

Abstract

摘要

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In vivo thrombin generation and subsequent APC formation are increased in factor V Leiden carriers.在携带因子V莱顿突变的个体中，体内凝血酶生成及随后的活化蛋白C形成增加。

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Influence of single nucleotide polymorphisms on thrombin generation in factor V Leiden heterozygotes.单核苷酸多态性对因子V莱顿杂合子凝血酶生成的影响。

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Thrombin generation and activated protein C resistance in the absence of factor V Leiden correlates with the risk of recurrent venous thromboembolism in women aged 18-65 years.在无因子 V 莱顿突变的情况下，凝血酶生成和活化蛋白 C 抵抗与 18-65 岁女性复发性静脉血栓栓塞风险相关。

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Increased Activated Protein C Response Rates Reduce the Thrombotic Risk of Factor V Leiden Carriers But Not of Prothrombin 20210G>A Carriers.活化蛋白 C 反应率升高可降低因子 V 莱顿携带者的血栓形成风险，但不能降低凝血酶原 20210G>A 携带者的血栓形成风险。

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Fibrinogen γ' increases the sensitivity to activated protein C in normal and factor V Leiden plasma.纤维蛋白原 γ' 增加了正常和因子 V 莱顿血浆对活化蛋白 C 的敏感性。

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