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Impaired activated protein C response rates indicate a thrombophilic phenotype in inherited thrombophilia.

作者信息

Reda Sara, Schwarz Nadine, Muller Jens, Oldenburg Johannes, Potzsch Bernd, Ruhl Heiko

机构信息

Institute of Experimental Hematology and Transfusion Medicine, University Hospital Bonn, Venusberg-Campus 1, 53127 Bonn.

出版信息

Haematologica. 2022 May 1;107(5):1197-1200. doi: 10.3324/haematol.2021.280573.

DOI:10.3324/haematol.2021.280573
PMID:35142157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9052898/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/9052898/53ae8d0d8de9/1071197.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/9052898/0b3e11f618ab/1071197.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/9052898/53ae8d0d8de9/1071197.fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/9052898/0b3e11f618ab/1071197.fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5229/9052898/53ae8d0d8de9/1071197.fig2.jpg

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Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease.全基因组关联分析静脉血栓栓塞症确定新的风险位点和与动脉血管疾病的遗传重叠。
Nat Genet. 2019 Nov;51(11):1574-1579. doi: 10.1038/s41588-019-0519-3. Epub 2019 Nov 1.
3
Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism.
基因组和转录组关联研究确定了 16 个静脉血栓栓塞的新易感性位点。
Blood. 2019 Nov 7;134(19):1645-1657. doi: 10.1182/blood.2019000435.
4
Increased Activated Protein C Response Rates Reduce the Thrombotic Risk of Factor V Leiden Carriers But Not of Prothrombin 20210G>A Carriers.活化蛋白 C 反应率升高可降低因子 V 莱顿携带者的血栓形成风险，但不能降低凝血酶原 20210G>A 携带者的血栓形成风险。
Circ Res. 2019 Aug 16;125(5):523-534. doi: 10.1161/CIRCRESAHA.119.315037. Epub 2019 Jul 17.
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In vivo thrombin generation and subsequent APC formation are increased in factor V Leiden carriers.在携带因子V莱顿突变的个体中，体内凝血酶生成及随后的活化蛋白C形成增加。
Blood. 2018 Mar 29;131(13):1489-1492. doi: 10.1182/blood-2017-12-823831. Epub 2018 Feb 21.
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Label-Free Kinetic Studies of Hemostasis-Related Biomarkers Including D-Dimer Using Autologous Serum Transfusion.使用自体血清输注对包括D-二聚体在内的止血相关生物标志物进行无标记动力学研究。
PLoS One. 2015 Dec 14;10(12):e0145012. doi: 10.1371/journal.pone.0145012. eCollection 2015.
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