Northwestern University Feinberg School of Medicine, Department of Obstetrics and Gynecology, Chicago, IL, USA.
Northwestern University Feinberg School of Medicine, Department of Pathology, Chicago, IL, USA.
J Perinatol. 2018 Jun;38(6):653-657. doi: 10.1038/s41372-018-0078-y. Epub 2018 Feb 21.
Abnormal umbilical cord coiling is associated with adverse perinatal outcomes; however, the etiology of the umbilical coiling pattern is poorly understood.
Retrospective cohort of all twin deliveries >20 weeks in 2014. Pregnancies were dichotomized by chorionicity and the umbilical coiling index (UCI) and placental cord insertion location were compared. In cases with one or both cords hypercoiled, the direction and pattern of coiling were compared by chorionicity. A similar analysis was performed stratified by zygosity.
Three hundred sisty two twin pairs were included; 26 (7.2%) monochorionic and 174 (87.0%) definitively dizygotic. Concordance in the UCI and coiling category were similar between dichorionic and monochorionic as well as dizygous and monozygous gestations, (73.2% vs 80.8%, p = 0.399 and 71.4% vs 80.8%, p = 0.399, respectively). Analyses of the coiling direction and pattern also demonstrated no difference by chorionicity or zygosity.
These data do not support a genetic basis for umbilical cord coiling.
脐带异常缠绕与不良围产结局相关；然而，脐带缠绕模式的病因仍不清楚。
2014 年对所有 20 周以上的双胎分娩进行回顾性队列研究。根据绒毛膜性将妊娠分为两类，并比较脐带缠绕指数（UCI）和胎盘脐带插入位置。在一条或两条脐带过度缠绕的情况下，按绒毛膜性比较缠绕的方向和模式。按同卵双生子和异卵双生子进行分层分析。
共纳入 362 对双胎；26 对（7.2%）为单绒毛膜性，174 对（87.0%）为确定的异卵双生子。双绒毛膜性和单绒毛膜性以及同卵双生子和异卵双生子妊娠的 UCI 和缠绕分类的一致性相似（73.2%与 80.8%，p=0.399 和 71.4%与 80.8%，p=0.399）。对缠绕方向和模式的分析也表明，绒毛膜性或同卵性均无差异。
这些数据不支持脐带缠绕的遗传基础。
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