线粒体基因组变异性：对细胞功能活性的影响。
Mitochondrial genome variability: the effect on cellular functional activity.
作者信息
Volobueva Aleksandrina S, Melnichenko Alexandra A, Grechko Andrey V, Orekhov Alexander N
机构信息
Laboratory of Gene Therapy, Biocad Biotechnology Company, Saint-Petersburg, Strelnya, Russia.
Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, Russian Academy of Sciences, Moscow, Russia.
出版信息
Ther Clin Risk Manag. 2018 Feb 9;14:237-245. doi: 10.2147/TCRM.S153895. eCollection 2018.
Abstract
Mitochondria are the key players in cell metabolism, calcium homeostasis, and reactive oxygen species (ROS) production. Mitochondrial genome alterations are reported to be associated with numerous human disorders affecting nearly all tissues. In this review, we discuss the available information on the involvement of mitochondrial DNA (mtDNA) mutations in cell dysfunction.
摘要
线粒体是细胞代谢、钙稳态和活性氧（ROS）产生的关键参与者。据报道，线粒体基因组改变与影响几乎所有组织的多种人类疾病有关。在这篇综述中，我们讨论了关于线粒体DNA（mtDNA）突变参与细胞功能障碍的现有信息。
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