Zhang Yingwei, Bi Lintao, Qiu Yuying, Zhao Tingting, Cao Mengshu, Ding Jingjing, Meng Fanqing, Cai Hourong
Department of Respiratory Diseases, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
Department of Oncology and Hematology, China-Japan Union Hospital Affiliated to Jilin University, Changchun, Jilin 130031, P.R. China.
Oncol Lett. 2018 Mar;15(3):3610-3613. doi: 10.3892/ol.2018.7753. Epub 2018 Jan 9.
The present study aimed to investigate the clinicopathological features of primary intravascular large B-cell lymphoma (IVLBCL) of the lung. The clinical and histopathological data of three patients, and the literature was reviewed. The Ethics Committees of Drum Tower Hospital approved the current study based on the three cases. Fever and respiratory symptoms were the main presenting symptoms. Serum lactate dehydrogenase and C-reactive protein were significantly increased. Diffuse ground glass opacities or nodular consolidations were seen on high resolution computed tomography. Lung biopsy revealed lymphoma cells in the lumen of small blood vessels. Tumor cells expressed cluster of differentiation 20 and melanoma associated antigen (mutated) 1. Primary pulmonary IVLBCL is extremely rare and its prognosis is poor. Full recognition of its clinical character and improvement of the diagnostic awareness may help to reduce missed diagnosis, and facilitate appropriate treatment.
本研究旨在探讨肺原发性血管内大B细胞淋巴瘤（IVLBCL）的临床病理特征。回顾了3例患者的临床和组织病理学资料，并复习了相关文献。基于这3例病例，鼓楼医院伦理委员会批准了本研究。发热和呼吸道症状是主要的临床表现。血清乳酸脱氢酶和C反应蛋白显著升高。高分辨率计算机断层扫描显示弥漫性磨玻璃影或结节状实变。肺活检显示小血管腔内有淋巴瘤细胞。肿瘤细胞表达分化簇20和黑色素瘤相关抗原（突变型）1。原发性肺IVLBCL极为罕见，预后较差。充分认识其临床特征并提高诊断意识可能有助于减少漏诊，并促进恰当治疗。
