Alnawaiseh M, Eter N
Klinik für Augenheilkunde, Universitätsklinikum Münster, Domagkstraße15, 48149, Münster, Deutschland.
Ophthalmologe. 2018 Sep;115(9):737-743. doi: 10.1007/s00347-018-0667-3.
Corneal densitometry, based on the Scheimpflug principle, is a useful noninvasive tool for quantitative evaluation of the optical quality of the cornea. It enables us to evaluate corneal transparency in the different corneal layers and different annuli. In this article, we discuss the basis of application of corneal densitometry measurements and summarize findings in patients with keratoconus.
This article is based on a selective literature review and analysis of own data.
Patients with keratoconus have significant higher corneal densitometry values compared to healthy controls. Densitometry values also correlate with the extent of the disease. In the first months after corneal cross-linking (CXL), haze formation occurs and leads to a decrease in corneal transparency, thus densitometry peaks. Long-term analysis of densitometric data have shown that corneal transparency then starts to decrease after 3 to 6 months, and improves further with time. At 24 to 36 months after CXL, corneal transparency levels might achieve physiological values.
Corneal transparency is reduced in patients with keratoconus. In the first months after CXL, haze formation and a reduction in corneal transparency can be observed, which subsequently improve with time.
基于Scheimpflug原理的角膜密度测量法是一种用于定量评估角膜光学质量的有用的非侵入性工具。它使我们能够评估不同角膜层和不同环带的角膜透明度。在本文中，我们讨论角膜密度测量的应用基础，并总结圆锥角膜患者的研究结果。
本文基于选择性文献综述和自身数据的分析。
与健康对照组相比，圆锥角膜患者的角膜密度测量值显著更高。密度测量值也与疾病程度相关。在角膜交联（CXL）后的最初几个月，会出现 haze 形成并导致角膜透明度降低，因此密度测量值达到峰值。对密度测量数据的长期分析表明，角膜透明度在3至6个月后开始下降，并随时间进一步改善。在CXL后24至36个月，角膜透明度水平可能达到生理值。
圆锥角膜患者的角膜透明度降低。在CXL后的最初几个月，可以观察到 haze 形成和角膜透明度降低，随后随时间改善。
