Chino Marco, Leone Linda, Zambrano Gerardo, Pirro Fabio, D'Alonzo Daniele, Firpo Vincenzo, Aref Diaa, Lista Liliana, Maglio Ornella, Nastri Flavia, Lombardi Angela
Department of Chemical Sciences, University of Napoli "Federico II," Via Cintia, Napoli, 80126, Italy.
Institute of Biostructures and Bioimages-National Research Council, Via Mezzocannone 16, Napoli, 80134, Italy.
Biopolymers. 2018 Aug;109(10):e23107. doi: 10.1002/bip.23107. Epub 2018 Feb 22.
Inspired by natural heme-proteins, scientists have attempted for decades to design efficient and selective metalloporphyrin-based oxidation catalysts. Starting from the pioneering work on small molecule mimics in the late 1970s, we have assisted to a tremendous progress in designing cages of different nature and complexity, able to accommodate metalloporphyrins. With the intent of tuning and controlling their reactivity, more and more sophisticated and diverse environments are continuously exploited. In this review, we will survey the current state of art in oxidation catalysis using iron- and manganese-porphyrins housed within designed or engineered protein cages. We will also examine the innovative metal-organic framework (MOF) systems, exploited to achieving an enzyme-like environment around the metalloporphyrin cofactor.
受天然血红素蛋白的启发，几十年来科学家们一直试图设计高效且具有选择性的基于金属卟啉的氧化催化剂。从20世纪70年代末关于小分子模拟物的开创性工作开始，我们见证了在设计能够容纳金属卟啉的不同性质和复杂性的笼状结构方面取得的巨大进展。为了调节和控制它们的反应活性，人们不断开发越来越复杂和多样的环境。在这篇综述中，我们将概述使用设计或工程化蛋白质笼中所含铁卟啉和锰卟啉进行氧化催化的当前技术水平。我们还将研究为在金属卟啉辅因子周围实现类似酶的环境而开发的创新金属有机框架（MOF）系统。
