Ghasemi Saba, Habibi Zohreh, Mohajeri Maryam, Yousefi Maryam
a Department of Chemistry, Ilam Branch , Islamic Azad University , Ilam , Iran.
b Faculty of Chemistry, Department of Pure Chemistry , Shahid Beheshti University , Tehran , Iran.
Nat Prod Res. 2019 Mar;33(6):835-842. doi: 10.1080/14786419.2017.1413563. Epub 2018 Feb 22.
The microbial transformations of peucedanin and oreoselon by the fungi Aspergillus niger and Aspergillus sp. were investigated for the first time. Incubation of peucedanin with A. niger yielded a new hydroxylated metabolite with high yield (56%), which was characterized as 2-(1-hydroxypropan-2-yl)-3-methoxy-7H-furo[3,2-g]chromen-7-one. Oreoselon was converted to a new reduced metabolite methyl 3-(2,3-dihydro-6-hydroxy-2-isopropyl-3-oxobenzofuran-5-yl)propanoate in biotransformation by Aspergillus sp. The structures of the metabolites were determined by spectroscopic methods including IR, EI-MS, H NMR, C NMR, and elemental analysis.
首次研究了黑曲霉和曲霉属真菌对前胡素和滨海前胡醇的微生物转化。前胡素与黑曲霉一起培养产生了一种高产率（56%）的新羟基化代谢产物，其被鉴定为2-(1-羟基丙-2-基)-3-甲氧基-7H-呋喃并[3,2-g]色烯-7-酮。滨海前胡醇在曲霉属真菌的生物转化中转化为一种新的还原代谢产物3-(2,3-二氢-6-羟基-2-异丙基-3-氧代苯并呋喃-5-基)丙酸甲酯。代谢产物的结构通过红外光谱、电子轰击质谱、氢核磁共振、碳核磁共振和元素分析等光谱方法确定。
