[Meta regression analysis of five heavy metal biotoxicity effects on ].

OBJECTIVE

To evaluate five heavy metal biotoxicity effects on with Meta regression analysis.

METHODS

The data were collected from the following electronic databases：PubMed, Web of Science, EBSCO, the Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wan Fang (Chinese) Databases and so on, and all updated through January 2004 to December 2014. A literature review was made on articles about Cd, Hg, Pb, As and Cr toxicity effects on , and the data was extracted from figure information by Scan It software. A Meta regression model was built by stata12.0 software, using toxicity indices such as the dependent variables, and different metals, concentrations, exposure time, and development stages of as independent variables.

RESULTS

The study articles asociated with heavy metal biotoxicity effects on were selected out, 10 studies of Cu, 12 studies of Cr, 12 studies of Pb, 12 studies of Cd, 3 studies of As and 14 studies of Hg. The mortality of toxicities of 5 heavy metals on ranked Hg > Pb > Cr> Cd>As; the biotoxicity of the indexes of body size based on development, generational time based on reproductive toxicity, body bend frequencies, and head thrash frequencies based on neurotoxicity ranked Hg > Pb > Cr > Cd; the biotoxicity ranked Hg > Pb > Cr> Cd>As by LC indexes of toxicities of 5 heavy metals on . The sensitivity analysis proved that the Meta regression model was reliable.

CONCLUSIONS

The biotoxicities on of Hg and Pb are stronger than Cr, Cd and As.