Degirmentepe Ece Nur, Gungor Sule, Kocaturk Emek, Kiziltac Utkan, Adas Mine, Ozekinci Selver, Khachemoune Amor
Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York, Dermatology Service, Veterans Affairs Medical Center, Brooklyn, New York.
Dermatol Online J. 2017 Aug 15;23(8):13030/qt50s903qh.
Acromegaly is a systemic syndrome caused by overproduction of growth hormone. Cutaneous, endocrine, cardiovascular, skeletal, and respiratory systems are affected. Cutaneous changes in acromegaly relate to overexpression of growth hormone and insulin-like growth factor 1 on skin cells and adnexa. Dermal glycosaminoglycan accumulation and edema cause skin distention that is most prominent in the face, hands, and feet. Oily skin with large pores, hypertrichosis, and excessive sweating are common features. Pigmented skin tags, acanthosis nigricans, and psoriasis are also encountered. Cutaneous manifestations of acromegaly are various and prominent, and are an important clue for the early diagnosis and treatment of this high-morbidity disorder.
肢端肥大症是一种由生长激素分泌过多引起的全身性综合征。皮肤、内分泌、心血管、骨骼和呼吸系统都会受到影响。肢端肥大症的皮肤变化与生长激素和胰岛素样生长因子1在皮肤细胞和附属器上的过度表达有关。真皮糖胺聚糖积聚和水肿导致皮肤扩张，在面部、手部和足部最为明显。毛孔粗大、多毛症和多汗是常见特征。还会出现色素性皮肤软纤维瘤、黑棘皮病和银屑病。肢端肥大症的皮肤表现多样且突出，是这种高发病率疾病早期诊断和治疗的重要线索。
