Laboratory of Epidemiology, Clinical Research and Public Health, Mohammed VI University Hospital Center, Faculty of Medicine and Pharmacy, University of Mohammed 1st, Oujda, Morocco.
Dermatol Online J. 2024 Jun 15;30(3). doi: 10.5070/D330363871.
Acromegaly is a rare systemic syndrome induced by the overproduction of growth hormone (GH) and insulin-like growth factor type one (IGF1). It is responsible for changes in the skeletal and soft tissue systems and it almost always occurs because of a pituitary adenoma. Amongst the skin complications related to acromegaly, cutis verticis gyrate (CVG) is occasionally found. It is a skin condition characterized by excessive growth of the skin of the scalp, resulting in furrows and folds. Only a few cases of this uncommon association have been reported in the literature. The present clinical case illustrates typical CVG associated with acromegaly. Imaging revealed a pituitary macroadenoma lesion and hormonal evaluation revealed elevated IGF1 and hypopituitarism. The patient underwent a transsphenoidal resection of the pituitary adenoma and the histopathological examination confirmed the diagnosis. The diagnosis of CVG is clinical, so radiologic assessments are generally not necessary. The management of acromegaly associated with CVG depends on controlling the serum levels of GH and IGF1. In some cases, specific injections or surgery can be used to minimize CVG.
肢端肥大症是一种由生长激素（GH）和胰岛素样生长因子 1 型（IGF1）过度产生引起的罕见全身综合征。它负责骨骼和软组织系统的变化，几乎总是由于垂体腺瘤引起。在与肢端肥大症相关的皮肤并发症中，偶尔会发现头皮回旋状皮肤皱褶（CVG）。这是一种以头皮过度生长为特征的皮肤状况，导致出现皱纹和褶皱。文献中仅报道了少数几例这种罕见的相关病例。本临床病例说明了与肢端肥大症相关的典型 CVG。影像学显示垂体大腺瘤病变，激素评估显示 IGF1 升高和垂体功能减退。患者接受了经蝶窦垂体腺瘤切除术，组织病理学检查证实了诊断。CVG 的诊断是临床诊断，因此通常不需要进行影像学评估。与 CVG 相关的肢端肥大症的治疗取决于控制 GH 和 IGF1 的血清水平。在某些情况下，可以使用特定的注射或手术来最小化 CVG。
