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用氨苯砜治疗的线状IgA大疱性皮肤病的中毒性表皮坏死松解症样表现。

A toxic epidermal necrolysis-like presentation of linear IgA bullous dermatosis treated with dapsone.

作者信息

Nguyen Julie K, Koshelev Misha V, Gill Bartley J, Boulavsky Jessica, Diwan Abdul Hafeez, Dao Harry

机构信息

Department of Dermatology, Baylor College of Medicine, Houston, Texas.

出版信息

Dermatol Online J. 2017 Aug 15;23(8):13030/qt4443157h.

Abstract

Linear IgA bullous dermatosis is a rare autoimmune vesiculobullous disease characterized by linear deposition of IgA along the basement membrane zone. It is classically idiopathic, but may also arise secondary to drug exposure. A heterogeneous spectrum of clinical features has been described, including a rare, morbid variant mimicking toxic epidermal necrolysis. Herein, we present a case of vancomycin-induced linear IgA bullous dermatosis that manifested clinically as toxic epidermal necrolysis and resolved with dapsone therapy.

摘要

线状IgA大疱性皮肤病是一种罕见的自身免疫性水疱大疱性疾病,其特征为IgA沿基底膜带呈线状沉积。该病通常为特发性,但也可能继发于药物暴露。已描述了一系列异质性的临床特征,包括一种罕见的、类似中毒性表皮坏死松解症的严重变体。在此,我们报告一例万古霉素诱导的线状IgA大疱性皮肤病,其临床表现为中毒性表皮坏死松解症,经氨苯砜治疗后痊愈。

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