Emge Drew A, Lewis Daniel J, Aung Phyu P, Duvic Madeleine
Department of Internal Medicine, Baylor College of Medicine, Houston, Texas.
Dermatol Online J. 2018 Jan 15;24(1):13030/qt9kq75581.
Mycosis fungoides (MF) is a T-cell, non-Hodgkin lymphoma that primarily involves the skin. Extracutaneous involvement, such as in the parotidgland, is characteristic of end-stage disease. Eosinophilic cellulitis, or Wells syndrome, is a rare inflammatory dermatitis that involves a dermal infiltrate of eosinophils. We report a case of an 80-year-old man with a long-standing diagnosis of stage IIB MF who acutely developed parotid gland involvement and marked hypereosinophilia that most likely represented eosinophilic cellulitis. Activated T cells from his MF were likely a trigger factor for the development of his eosinophilic cellulitis. To our knowledge, this is the first reported case of an MF patient with atypical parotid gland involvement andeosinophilic cellulitis.
蕈样肉芽肿（MF）是一种主要累及皮肤的T细胞非霍奇金淋巴瘤。皮肤外受累，如累及腮腺，是终末期疾病的特征。嗜酸性蜂窝织炎，即韦尔斯综合征，是一种罕见的炎症性皮肤病，其特征为真皮内有嗜酸性粒细胞浸润。我们报告一例80岁男性患者，长期诊断为IIB期MF，急性出现腮腺受累及明显的嗜酸性粒细胞增多，很可能代表嗜酸性蜂窝织炎。来自其MF的活化T细胞可能是其嗜酸性蜂窝织炎发生的触发因素。据我们所知，这是首例报告的MF患者出现非典型腮腺受累及嗜酸性蜂窝织炎的病例。
