Rato M, Gil F, Monteiro A F, Aranha J, Tavares E
Dermatology Department of Hospital de Santarém EPE, Santarém, Portugal.
Dermatol Online J. 2018 Jan 15;24(1):13030/qt3x33s9m7.
A 55-year-old man presented with a history of asymptomatic, bilateral, figurate dermatosis consisting of erythematous, annular, linear, andarciform, indurated nodules and plaques on the lateral walls of thorax, flanks, and hypogastrium. His medical history was positive for chronic hepatitis C. Skin biopsy was compatible with the diagnosisof interstitial granulomatous dermatitis. Additionalinvestigation revealed positive rheumatoid factor, antinuclear antibodies, and cryoglobulins. Thepatient started treatment with high-potency topical corticosteroid. After 12 weeks of treatment there was a partial clinical improvement of thedermatosis. Interstitial granulomatous dermatitis exhibits a distinct histopathological pattern with a diverse clinical appearance, which can be associated with autoimmune systemic diseases, neoplasms, several drugs, and infections. Optimal therapy for this condition is yet to be established, but topical corticosteroids have been a mainstay of treatment.
一名55岁男性，有双侧无症状图形性皮肤病病史，表现为胸部侧壁、胁腹和下腹部的红斑、环状、线状和弧形硬结性结节及斑块。他有慢性丙型肝炎病史。皮肤活检结果符合间质性肉芽肿性皮炎的诊断。进一步检查发现类风湿因子、抗核抗体和冷球蛋白呈阳性。患者开始使用高效外用糖皮质激素治疗。治疗12周后，皮肤病有部分临床改善。间质性肉芽肿性皮炎呈现出独特的组织病理学模式，临床表现多样，可与自身免疫性全身性疾病、肿瘤、多种药物及感染相关。该病的最佳治疗方法尚未确立，但外用糖皮质激素一直是主要的治疗手段。
