Antunes Joana, Pacheco David, Travassos Ana Rita, Soares-Almeida Luís Miguel, Filipe Paulo, Sacramento-Marques Manuel
Dermatology Service, Santa Maria Hospital, Hospital Center North Lisbon, Portugal.
An Bras Dermatol. 2012 Sep-Oct;87(5):748-51. doi: 10.1590/s0365-05962012000500013.
A 54-year-old female presented with recurrent, widespread, erythematous, painful plaques, over a 3-month period. Skin biopsy was compatible with interstitial granulomatous dermatitis. Additional investigation revealed hypothyroidism and positive anti-thyroid antibodies. Normalization of thyroid function and high-potency topical corticosteroids provided only transitory improvement of the dermatosis. Interstitial granulomatous dermatitis is a histologic inflammatory reaction, with variable cutaneous expression. It has been reported in association with several drugs, lymphoproliferative diseases and autoimmune disorders, such as rheumatoid arthritis, systemic lupus erythematosus and vasculitis, but association with autoimmune thyroiditis is rare. Optimal therapy for this condition is yet to be established, but topical corticosteroids have been a mainstay of treatment. In most cases, this disease is characterized by flares and remissions.
一名54岁女性在3个月内出现反复发作的广泛红斑性疼痛斑块。皮肤活检结果符合间质性肉芽肿性皮炎。进一步检查发现甲状腺功能减退以及抗甲状腺抗体呈阳性。甲状腺功能正常化和强效外用糖皮质激素仅使皮肤病得到短暂改善。间质性肉芽肿性皮炎是一种组织学炎症反应，有多种皮肤表现形式。已有报道称其与多种药物、淋巴增殖性疾病及自身免疫性疾病相关，如类风湿关节炎、系统性红斑狼疮和血管炎，但与自身免疫性甲状腺炎相关的情况较为罕见。针对这种疾病的最佳治疗方法尚未确定，但外用糖皮质激素一直是主要治疗手段。在大多数情况下，这种疾病的特点是病情有发作和缓解。
