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免疫原性分枝杆菌引起的皮肤感染:一例欧洲病例报告及文献复习

Cutaneous infection due to Mycobacterium immunogenum: an European case report and review of the literature.

作者信息

Garcia-Zamora Elena, Sanz-Robles Henar, Elosua-Gonzalez Marta, Rodriguez-Vasquez Ximena, Lopez-Estebaranz Jose Luis

机构信息

Department of Dermatology, Hospital Universitario Fundacion Alcorcon, Madrid, Spain.

出版信息

Dermatol Online J. 2017 Oct 15;23(10):13030/qt9zg5r07t.

Abstract

(no more than 200 words): In the last few years, the incidence of cutaneous infections caused by nontuberculous mycobacteria is increasing. Since Mycobacterium immunogenum was first described in 2001, few case reports have been described, all of them in the American continent. We report a case with cutaneous infection caused by this newly discovered NTB in Europe.A 65-year-old woman presented with a 3-months history of pruritic lesions on abdomen. Examination revealed erythematous inflammatory papules, pustules, and crusts. Three weeks later, mycobacteria were cultured from the biopsy specimen. Mycobacterium immunogenum was identified based on susceptibility test results and polymerase chain reaction (PCR) restriction enzyme analysis. Treatment with clarithromycin was started. M. immunogenum is a nontuberculous mycobacterium that was first described by Wilson et al. in 2001 as a rapidly growing variety and new species in the Mycobacterium chelonae-Mycobacterium abscessus group. PCR-restriction analysis of a 439-bp segment of the hsp65 gene and/or sequencing the species-specific region of the 16S rDNA can confirm this new species. Since the description of M. immunogenum, 8 clinical case reports have been published, most involving cutaneous infections and all of them in the American continent. We present a case of cutaneous infection caused by M. immunogenum in a Spanish woman.

摘要

(不超过200字):在过去几年中,非结核分枝杆菌引起的皮肤感染发病率不断上升。自2001年首次描述免疫分枝杆菌以来,仅有少数病例报告,且均来自美洲大陆。我们报告了欧洲首例由这种新发现的非结核分枝杆菌引起的皮肤感染病例。一名65岁女性腹部出现瘙痒性皮损3个月。检查发现有红斑性炎性丘疹、脓疱及痂皮。三周后,活检标本培养出分枝杆菌。根据药敏试验结果及聚合酶链反应(PCR)限制性酶切分析鉴定为免疫分枝杆菌。开始用克拉霉素治疗。免疫分枝杆菌是一种非结核分枝杆菌,2001年由威尔逊等人首次描述为龟分枝杆菌-脓肿分枝杆菌组中的快速生长变种和新物种。对hsp65基因439bp片段进行PCR限制性分析和/或对16S rDNA的物种特异性区域进行测序可确认该新物种。自免疫分枝杆菌被描述以来,已发表8例临床病例报告,大多涉及皮肤感染,均来自美洲大陆。我们报告了一名西班牙女性由免疫分枝杆菌引起的皮肤感染病例。

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