Arnold Morgan, Wilkerson Michael
University of Texas Medical Branch at Galveston Department of Dermatology Galveston, Texas.
Dermatol Online J. 2017 Oct 15;23(10):13030/qt49k2k7xt.
A 49-year old woman was hospitalized for generalized rash and pruritus following the administration of ophthalmic drops containing ciprofloxacin to treat conjunctivitis. Physical examination demonstrated diffuse erythematous papules and plaques with a targetoid appearance, injected sclera, and multiple erosions in the oropharynx. Skin biopsy confirmed a diagnosis of erythema multiforme major. The eye drops were discontinued and supportive treatment was initiated; the patient recovered in four weeks and was discharged from the hospital. Although cases such as this are rare, it is important that physicians take a thorough medication history from all patients with suspected erythema multiforme, including topical and ophthalmic medications. Prompt discontinuation of the offending agent can hasten patient recovery and optimize outcomes.
一名49岁女性因使用含环丙沙星的眼药水治疗结膜炎后出现全身性皮疹和瘙痒而住院。体格检查发现弥漫性红斑丘疹和斑块，呈靶样外观，巩膜充血，口咽部有多处糜烂。皮肤活检确诊为重症多形红斑。停用眼药水并开始支持治疗；患者四周后康复出院。虽然此类病例罕见，但医生对所有疑似多形红斑的患者进行全面用药史调查很重要，包括局部用药和眼药水。迅速停用致病药物可加速患者康复并优化治疗结果。
