Department of Chemistry , University of Science and Technology of China , Hefei , 230026 , P. R. China.
J Agric Food Chem. 2018 Mar 21;66(11):2925-2933. doi: 10.1021/acs.jafc.7b04615. Epub 2018 Feb 27.
Natural halloysite (AlSiO(OH)· nHO) nanotubes (HNT) are clay materials with hollow tubular structure and are widely applied in many fields. Many in vitro studies indicate that HNTs exhibit a high level of biocompatibility; however, the in vivo toxicity of HNTs remains unclear. In this study, the biodistribution and pulmonary toxicity of the purified HNTs in mice were investigated after intragastric administration for 30 days. HNTs have high stability in biological conditions. Oral administration of HNTs caused significant Al accumulation predominantly in the lung with relative slight effects on Si biodistribution. Oral administration of HNTs stimulated the growth of the mice at low dose (5 mg/kg BW) with no pulmonary toxicity but inhibited the mouse growth and resulted in oxidative stress and inflammation in lung at high dose (50 mg/kg BW). In addition, oral HNTs at high dose could be absorbed from the gastrointestinal tract and deposited in lung and could also induce pulmonary fibrosis.
天然埃洛石（AlSiO(OH)·nH2O）纳米管（HNT）是具有中空管状结构的粘土材料，广泛应用于许多领域。许多体外研究表明，HNTs 表现出很高的生物相容性；然而，HNTs 的体内毒性尚不清楚。在这项研究中，在经口给予 30 天后，研究了纯化的 HNTs 在小鼠体内的分布和肺部毒性。HNTs 在生物条件下具有很高的稳定性。经口给予 HNTs 导致 Al 主要在肺部蓄积，而 Si 的分布相对较少受到影响。低剂量（5mg/kgBW）的经口给予 HNTs 刺激小鼠生长，但无肺部毒性，但高剂量（50mg/kgBW）抑制小鼠生长并导致肺部氧化应激和炎症。此外，高剂量的经口 HNTs 可从胃肠道吸收并沉积在肺部，并可诱导肺纤维化。
